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REVIEW article

Front. Genet.

Sec. Applied Genetic Epidemiology

Volume 16 - 2025 | doi: 10.3389/fgene.2025.1624512

This article is part of the Research TopicGenetics (SKINOMICS): New Trends in Skin Aging Research and Clinical ApplicationView all 5 articles

The Role of Serine Protease Inhibitors in Dermatoses

Provisionally accepted
  • 1Fuzhou First Hospital, Fuzhou, China
  • 2Xinxiang Central Hospital, xinxiang, China
  • 3Charité-Universitätsmedizin Berlin, Berlin, Germany

The final, formatted version of the article will be published soon.

The balance between proteases and their inhibitors is essential for maintaining the structural and functional homeostasis of the skin. Numerous studies have shown that serine protease inhibitors are highly expressed in the skin and play diverse roles in preserving its physiological integrity. Among them, SERPINs have been closely linked to various skin disorders—for instance, mutations in SERPINB7 are associated with palmoplantar keratoderma, while SERPINA1 has been implicated in the pathogenesis of adult-onset immunodeficiency syndrome and generalized pustular psoriasis, both of which currently have limited treatment options. This review focuses on the biological functions of SERPINs in the skin, aiming to provide insights into the mechanisms underlying SERPIN-related skin diseases and to facilitate the development of targeted therapeutic strategies.

Keywords: Serpins, reactive center loop, dermatoses, Palmoplantar keratoderma, RCL

Received: 07 May 2025; Accepted: 09 Sep 2025.

Copyright: © 2025 Xiao, Kang, Zhuo, Li and Tan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Rui Li, 292430384@qq.com
Yingjian Tan, dr.yingjian.tan@gmail.com

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