REVIEW article
Front. Genet.
Sec. RNA
Circular RNAs at the Crossroads of Acute Pancreatitis: Bridging Molecular Mechanisms to Diagnostic and Therapeutic Innovations
Provisionally accepted
- 1West China Hospital, Sichuan University, Chengdu, China
- 2Sichuan Academy of Medical Sciences and Sichuan People's Hospital, Chengdu, China
- 3Xi'an Jiao Tong University Stomatology Hospital, Xi'an, China
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Acute pancreatitis (AP) is a severe inflammatory condition that frequently leads to systemic inflammatory response syndrome and multiple organ failure. Despite the increasing occurrence, targeted therapies remain unavailable. CircRNAs have recently been implicated in AP pathogenesis, regulating biological processes such as apoptosis, pyroptosis , and inflammation through mechanisms including miRNA sponging, protein scaffolding, and translation. Their disease-specific roles make them promising candidates for clinical translation. This review highlights the potential of circRNAs as novel diagnostic tools and therapeutic targets in AP, aiming to guide future advancement of innovative biomarkers and therapeutic strategies.
Keywords: CircRNAs, acute pancreatitis, biomarker, Therapeutic tool, Chronic pancreaititis
Received: 20 Jun 2025; Accepted: 10 Nov 2025.
Copyright: © 2025 CHEN, Chen and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: JING CHEN, chen998872@outlook.com
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