ORIGINAL RESEARCH article
Front. Genet.
Sec. Computational Genomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1651794
Identification of platelet function-related genes in STEMI patients
Provisionally accepted
- Affiliated Hospital of Zunyi Medical University, Zunyi, China
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Background: ST-elevation myocardial infarction (STEMI) is characterized by acute severe ischemia leading to extensive myocardial necrosis, with platelets playing a key role in its pathogenesis. This study aimed to identify platelet function-related biomarkers in STEMI. Methods: The GSE59867 dataset was analyzed to identify differentially expressed genes (DEGs) between STEMI patients and controls. Platelet function-related DEGs (DEPRGs) were obtained by intersecting DEGs with platelet-related genes. Enrichment analyses (GO and KEGG) were performed, a protein-protein interaction (PPI) network was constructed, and hub genes were identified. Diagnostic value was assessed using ROC analysis, with further validation in an independent dataset (GSE123342) and via qPCR in human blood and mouse cardiac tissue. Results: A total of 245 DEPRGs were identified, enriched primarily in hemostasis, coagulation, and platelet activation (adjusted P < 0.05). Eleven hub genes were screened, among which GRB2, MAPK1, MAPK3, PIK3CA, AKT1, and PIK3R1 showed strong diagnostic performance (AUC > 0.7). Independent validation confirmed consistent expression changes and AUC > 0.7 for MAPK3 and GRB2. qPCR further verified the differential expression of GRB2 and MAPK3 in STEMI patients and mouse models (P < 0.05). Conclusion: MAPK3 and GRB2 were identified as key platelet function-related genes with potential diagnostic value for STEMI, demonstrating high clinical relevance.
Keywords: STEMI, Key gene, platelet-related genes, diagnosis, cvd
Received: 22 Jun 2025; Accepted: 08 Sep 2025.
Copyright: © 2025 Zhu, Yang, Guo, Yang and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bei Shi, Affiliated Hospital of Zunyi Medical University, Zunyi, China
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