ORIGINAL RESEARCH article
Front. Genet.
Sec. Cancer Genetics and Oncogenomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1652603
This article is part of the Research TopicAdvancements in head and neck tumor treatment strategy driven by the perspective of precision oncologyView all 5 articles
The comparison of the Prognostic Value of different inflammation-related indicators in patients with Oral Squamous Cell Carcinoma
Provisionally accepted
Aoming Cheng1
Kaixiong Wei1
Qiaoshi Xu1Chong Wang1
Bo Li1
Huan Liu1
Lirui Zhang1
Hanchen Zhou1Yu Huang1Yiming Zhang1Xue Zhang1Hao Wang1Chang Liu1Teng Ma2Jingrui Li1
Zhengxue Han1Zhien Feng1*- 1Beijing Stomatological Hospital, Capital Medical University, Beijing, China
- 2Beijing Huairou Hospital Stomatology Department, Beijing, China
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Background: This study aimed to determine the prognostic significance of inflammation markers for patients with oral squamous cell carcinoma (OSCC) and sought to analyze the reasons behind it and its value for clinical guidance.Methods: This study enrolled 624 patients with OSCC who were surgically treated in our hospital.Clinical baseline data and peripheral blood routine/biochemical parameters were collected within one week before surgery. The Kaplan-Meier analysis and Cox multifactor regression analysis were performed for statistical analysis. Time-dependent receiver operating characteristic curves (ROC) were used to explore the timeliness of inflammation-related indicators.The Kaplan-Meier analysis revealed that patients with a high-inflammatory trend had significantly shorter overall survival (OS) and disease-free survival (DFS) compared to the patients with a low-inflammatory trend (P<0.05). Cox multivariate regression analysis demonstrated that albumin-lymphocyte index (ALI) and prognostic nutritional index (PNI) were correlated with OS of OSCC patients. Additionally, Subgroup analysis found that ALI and PNI served as independent prognostic factors for OS in male patients. In age-stratified analyses, ALI and PNI also emerged as independent predictors of OS for patients <60 years. time-dependent ROC, which ALI demonstrated the best predictive performance for short-term postoperative prognosis (area under the curve (AUC) = 0.74).Conclusions: ALI and PNI are valuable prognostic indicators in the short term after surgery for young male patients under 60 years old with OSCC.
Keywords: OSCC, inflammation-related indicators, Prognostic nutritional index (PNI), Advanced Lung Cancer Inflammation Index(ALI), prognosis
Received: 23 Jun 2025; Accepted: 27 Jul 2025.
Copyright: © 2025 Cheng, Wei, Xu, Wang, Li, Liu, Zhang, Zhou, Huang, Zhang, Zhang, Wang, Liu, Ma, Li, Han and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhien Feng, Beijing Stomatological Hospital, Capital Medical University, Beijing, China
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