REVIEW article
Front. Genet.
Sec. Cancer Genetics and Oncogenomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1666561
This article is part of the Research TopicCancer Cell Metabolism and Tumor Microenvironment RemodelView all 9 articles
Epigenetic and Metabolic Reprogramming via Nanotechnology: A Synergistic Approach to Cancer Vaccination in Lung Tumors
Provisionally accepted
- 1Affiliated Hospital of Chengdu University, Chengdu, China
- 2The Affiliated Hospital of Southwest Medical University, Luzhou, China
- 3The First People's Hospital of Neijiang, Neijiang, China
- 4Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China
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Abstract Cancer vaccines represent a promising therapeutic modality in immuno-oncology, yet their efficacy is severely constrained within the immunosuppressive microenvironment of lung tumors. Metabolic reprogramming and epigenetic dysregulation are now understood as critical, interconnected determinants that orchestrate tumor microenvironment (TME) immunosuppression and fundamentally shape anti-tumor immune responses. This review comprehensively examines the mechanistic interplay between metabolic reprogramming and epigenetic regulation, and how nanoplatform technologies can be engineered to modulate these axes to augment cancer vaccine efficacy. We analyze advanced nano-delivery system design strategies, the synergistic effects of combining metabolic intervention with epigenetic modification, and their application in overcoming the formidable barriers of the lung TME. By integrating recent advances in nanotechnology, epigenetics, and tumor immunometabolism, we provide critical insights into the development of next-generation cancer vaccines. Furthermore, we propose a novel conceptual framework—the Epi-Met-Immune Synergistic Network—to dissect these interactions and identify key nodes for rational therapeutic intervention, aiming to enhance and sustain durable anti-tumor immunity.
Keywords: metabolic reprogramming, Epigenetic regulation, Nanoplatforms, Cancer Vaccines, Immunosuppression, lung tumors
Received: 21 Aug 2025; Accepted: 16 Sep 2025.
Copyright: © 2025 Xu, Zhang, Yu, Ma, Li, Chen, Yuan, Lin and Cui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Sheng Lin, lslinsheng@163.com
Ran Cui, cr100492@gmail.com
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