Your new experience awaits. Try the new design now and help us make it even better

CORRECTION article

Front. Genet., 10 September 2025

Sec. Genetics of Common and Rare Diseases

Volume 16 - 2025 | https://doi.org/10.3389/fgene.2025.1676267

Correction: Identification and functional characteristics of a novel splice site variant in L1CAM caused X-linked hydrocephalus

This article is a correction to:

  1. Identification and functional characteristics of a novel splice site variant in L1CAM caused X-linked hydrocephalus

    1. Read original article
Shijie Zhou,Shijie Zhou1,2Hao Zhang,Hao Zhang1,2Xue Li,Xue Li1,3Quan Chen,Quan Chen1,2Zhihong Xu, Zhihong Xu1,3*
  • 1Department of Reproductive Medicine Center, Deyang People’s Hospital, Deyang, Sichuan, China
  • 2Deyang Key Laboratory of Birth Defects Prevention and Control, Deyang People’s Hospital, Deyang, Sichuan, China
  • 3Department of Obstetrics and Gynecology, Deyang People’s Hospital, Deyang, Sichuan, China

A Correction on
Identification and functional characteristics of a novel splice site variant in L1CAM caused X-linked hydrocephalus

by Zhou S, Zhang H, Li X, Chen Q and Xu Z (2025). Front. Genet. 16:1588709. doi: 10.3389/fgene.2025.1588709

In the published article, there was an error in the Result Section, Bioinformatic analysis and pathogenicity classification, Paragraph 3.

The corrected text appears below.

“Based on the American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP) guidelines, the variant was classified as pathogenic (PVS1 +PM2 + PS3 + PP4). The PVS1 criterion was met due to the mutation affecting a canonical splice site, PM2 due to the absence of the variant in population databases, PS3 due to in vitro validation of minigene assay, and PP4 due to fetus’s phenotype and family history is highly specific for X-linked hydrocephalus with L1CAM genetic etiology.”

The original article has been updated.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: L1CAM, X-linked hydrocephalus, splice site variant, prenatal diagnostic, minigene

Citation: Zhou S, Zhang H, Li X, Chen Q and Xu Z (2025) Correction: Identification and functional characteristics of a novel splice site variant in L1CAM caused X-linked hydrocephalus. Front. Genet. 16:1676267. doi: 10.3389/fgene.2025.1676267

Received: 30 July 2025; Accepted: 29 August 2025;
Published: 10 September 2025.

Edited and reviewed by:

Andrea Bianconi, University of Genoa, Italy

Copyright © 2025 Zhou, Zhang, Li, Chen and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Zhihong Xu, MTUxODEzMzkzN0BxcS5jb20=

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.