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MINI REVIEW article

Front. Genet.

Sec. RNA

Volume 16 - 2025 | doi: 10.3389/fgene.2025.1681666

This article is part of the Research TopicEpigenetic Modifications in Drugs and DiseasesView all articles

Recent Progress of DNA Methylation in Psoriasis

Provisionally accepted
Zhaoping LinZhaoping Lin1Xiaoting WuXiaoting Wu2Xuqin HongXuqin Hong3Dongying LuoDongying Luo1Hui LiHui Li1Fei MaFei Ma4Cong HuangCong Huang1Bo YuBo Yu1Jing GaoJing Gao2*Changbing ShenChangbing Shen1*
  • 1Department of Dermatology, Shenzhen Hospital, Peking University, Shenzhen, China
  • 2Department of Dermatology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
  • 3Department of General Practice, The Second People's Hospital of Futian District, Shenzhen, China
  • 4Department of Anesthesiology, The Second Clinical Medical School of Anhui Medical University, Hefei, China

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Psoriasis is a chronic, recurrent, inflammatory disease that is affected by genetic, immunological, epigenetic, and environmental factors. With the development of biotechnology, research on the pathogenesis of psoriasis has deeply focused on the field of epigenetics, and great progress has been made. Epigenetics is the study of heritable changes in gene expression or cell phenotypes without altering the DNA sequence. DNA methylation (DNAm) alterations are the most common epigenetic phenomena and are widely studied. Many studies have shown that DNAm plays a key role in the pathogenesis of psoriasis, and some differentially methylated sites may be potential targets for the treatment of psoriasis. Here, we review and summarize the recent progress in DNAm in psoriasis.

Keywords: Psoriasis, epigenetics, DNA Methylation, Pathogenesis, progress

Received: 07 Aug 2025; Accepted: 11 Sep 2025.

Copyright: © 2025 Lin, Wu, Hong, Luo, Li, Ma, Huang, Yu, Gao and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Jing Gao, Department of Dermatology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
Changbing Shen, Department of Dermatology, Shenzhen Hospital, Peking University, Shenzhen, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material