REVIEW article
Front. Genome Ed.
Sec. Genome Editing Tools and Mechanisms
This article is part of the Research TopicRecent Advances in Genome Editing Technology and Its Multifaceted Applications in Medicine, Agriculture, and CosmeticsView all articles
Reconstructing the complex architecture of the genome with molecular scissors: Applying genome editing technology in precision medicine
Provisionally accepted
- National Institute of Pharmaceutical Education and Research, Kolkata, Kolkata, India
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Our past, present, and future are governed by the grand design of the genetic blueprint, which was mapped more than two decades back. While the eloquent design of our genome results from millions of years of evolution and has reached a near-perfect stage, unwanted flaws and mistakes in individual genomes can make their life miserable and worth intervention. The advent of technologies to manipulate the grand design and make it congenial for the individual has given new hope. Here, we discuss how gene editing technologies have progressed and how some of the technologies have become indispensable gears in precision medicine.
Keywords: CRISPR, Genome editing, precision medicine, TALEN, ZFN
Received: 07 Dec 2025; Accepted: 07 Jan 2026.
Copyright: © 2026 Khan, Das, Barik, Arumugam and Chattopadhyay. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Somasundaram Arumugam
Shiladitya Chattopadhyay
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.