Frontiers in Genome Editing | Genome Editing in Human Health and Disease

Review

Published on 26 Aug 2025

Stem cell and CRISPR/Cas9 gene editing technology in Alzheimer’s disease therapy: from basic research to clinical innovation

in Genome Editing in Human Health and Disease

Cong He
Baojiang Chen
Ciai Yan
Xiaoqing Zhou

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1612868

1,249 views

Perspective

Published on 20 Aug 2025

Ethical dimensions and societal implications: ensuring the social responsibility of CRISPR technology

in Genome Editing in Human Health and Disease

Irfan Biswas

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1593172

1,899 views

Review

Accepted on 25 Jul 2025

Rewriting the Script: Gene Therapy and Genome Editing for Von Willebrand Disease

in Genome Editing in Human Health and Disease

Alastair Barraclough
Isabel Bär
Tirsa Van Duijl
Karin Fijnvandraat
Jeroen C.J. Eikenboom
Frank W.G. Leebeek
Ruben Bierings
Jan Voorberg
Despoina Trasanidou

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1620438

509 views

Brief Research Report

Published on 23 Jul 2025

CRISPR-Cas9 editing of TNFAIP3 variants in salivary gland epithelial cells to study Sjögren’s disease pathogenesis

in Genome Editing in Human Health and Disease

Subhashis Ghosh
Qisheng Tu
Zoe Xiaofang Zhu
Sreelakshmi Panginikkod
Jake Jinkun Chen

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1625393

1,056 views

Mini Review

Accepted on 14 Jul 2025

In Pursuit of an HIV Cure: from Stem Cell Transplants to Gene Therapies

in Genome Editing in Human Health and Disease

Jennifer Clees
Maya Basic
Pedro Cruz
Servio Ramirez
Allison M Andrews

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1634193

1,459 views

Original Research

Published on 30 Apr 2025

Efficient GBA1 editing via HDR with ssODNs by outcompeting pseudogene-mediated gene conversion upon CRISPR/Cas9 cleavage

in Genome Editing in Human Health and Disease

Joseph S. Lagas
Monica F. Sentmanat
Xiaoxia Cui

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1581743

2,597 views

Original Research

Published on 04 Apr 2025

Mapping the therapeutic landscape of CRISPR-Cas9 for combating age-related diseases

in Genome Editing in Human Health and Disease

Qiyu He
Yida Wang
Zhimin Tan
Xian Zhang
Chao Yu
Xiaoqin Jiang

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1558432

3,174 views
2 citations

Review

Published on 12 Dec 2024

Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine

in Genome Editing in Human Health and Disease

Sarkar Sardar Azeez
Rahin Shareef Hamad
Bahra Kakamin Hamad
Mudhir Sabir Shekha
Peter Bergsten

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1509924

17,549 views
14 citations

Original Research

Published on 16 Oct 2024

Beyond the traditional distinctions of genome editing: evaluating a vulnerability framework

in Genome Editing in Human Health and Disease

Ioanna Angelioudaki
Ana Ruxandra Badea
Martina Bodo
Daniel Fernández-Soto
Emmanouela Sevasti Karyampa
Adam Kokkinakis
Nikolaos Kolisis
Xenia Kominea
Sandra Ozáez Armijos
Simon Vogel

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1426228

3,102 views

Review

Published on 09 Oct 2024

The potential of HBV cure: an overview of CRISPR-mediated HBV gene disruption

in Genome Editing in Human Health and Disease

Zhi Q. Yao
Madison B. Schank
Juan Zhao
Mohamed El Gazzar
Ling Wang
Yi Zhang
Addison C. Hill
Puja Banik
Jaeden S. Pyburn
Jonathan P. Moorman

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1467449

5,980 views
5 citations

Review

Published on 23 Aug 2024

In vivo liver targeted genome editing as therapeutic approach: progresses and challenges

in Genome Editing in Human Health and Disease

Chiara Simoni
Elena Barbon
Andrés F. Muro
Alessio Cantore

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1458037

6,014 views
5 citations

Original Research

Published on 28 May 2024

CRISPR-Cas9 immune-evasive hESCs are rejected following transplantation into immunocompetent mice

in Genome Editing in Human Health and Disease

Henriette Reventlow Frederiksen
Alexandra Glantz
Kåre Kryger Vøls
Søren Skov
Pernille Tveden-Nyborg
Kristine Freude
Ulrik Doehn

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1403395

3,363 views
2 citations

Editorial

Published on 20 Mar 2024

Editorial: Prevention of viral diseases by gene targeting

in Genome Editing in Human Health and Disease

Fan Luo
Qiankun Wang
Shuliang Chen

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1395468

2,594 views
1 citation

Review

Published on 06 Mar 2024

Epigenetic editing for autosomal dominant neurological disorders

in Genome Editing in Human Health and Disease

Jennifer J. Waldo
Julian A. N. M. Halmai
Kyle D. Fink

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1304110

5,189 views
4 citations

Original Research

Published on 01 Mar 2024

Nuclease-free precise genome editing corrects MECP2 mutations associated with Rett syndrome

in Genome Editing in Human Health and Disease

Swati Bijlani
Ka Ming Pang
Lakshmi V. Bugga
Sampath Rangasamy
Vinodh Narayanan
Saswati Chatterjee

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1346781

4,342 views
4 citations

Original Research

Published on 04 Jan 2024

Computational analysis of cas proteins unlocks new potential in HIV-1 targeted gene therapy

in Genome Editing in Human Health and Disease

Will Dampier
Rachel Berman
Michael R. Nonnemacher
Brian Wigdahl

Frontiers in Genome Editing

doi 10.3389/fgeed.2023.1248982

4,111 views
5 citations