Frontiers in Genome Editing | Genome Editing in Human Health and Disease

Original Research

Published on 29 Sep 2025

CRISPR-mediated generation of a tumor-associated antigen-deficient Raji platform to investigate antigen loss in CAR-T cell therapy

in Genome Editing in Human Health and Disease

Aditya Ramdas Iyer
Mehwish Nafiz
Pragya Gupta
Arvinden VR
Vinodh Saravanakumar
Mohammad Sufyan Ansari
Md Shakir
Tanveer Ahmad
Sivaprakash Ramalingam

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1649993

935 views

Editorial

Published on 22 Sep 2025

Editorial: Insights in genome editing in human health and disease 2023/2024

in Genome Editing in Human Health and Disease

Baisong Lu
Haiwei Mou
Chen Liang

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1697828

459 views

Review

Published on 22 Sep 2025

Rewriting the script: gene therapy and genome editing for von Willebrand Disease

in Genome Editing in Human Health and Disease

Alastair Barraclough
Isabel Bär
Tirsa van Duijl
Karin Fijnvandraat
Jeroen C. J. Eikenboom
Frank W. G. Leebeek
Ruben Bierings
Jan Voorberg
Despoina Trasanidou

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1620438

1,107 views

Perspective

Accepted on 18 Sep 2025

Proceedings From Second Annual GenE-HumDi (COST Action 21113) Meeting

in Genome Editing in Human Health and Disease

María Ortíz-Bueno
Iris Ramos-Hernández
Luis Algeciras Jiménez
Nechama Kalter
Juan Roberto Rodriguez-Madoz
José Bonafont
Rajeevkumar Raveendran Nair
Oliver Feeney
Laura Torella
Lluis Montoliu

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1667329

186 views

Mini Review

Published on 05 Sep 2025

In pursuit of an HIV cure: from stem cell transplants to gene therapies

in Genome Editing in Human Health and Disease

Jennifer Clees
Maya Basic
Pedro E. Cruz
Servio H. Ramirez
Allison M. Andrews

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1634193

2,750 views

Review

Published on 26 Aug 2025

Stem cell and CRISPR/Cas9 gene editing technology in Alzheimer’s disease therapy: from basic research to clinical innovation

in Genome Editing in Human Health and Disease

Cong He
Baojiang Chen
Ciai Yan
Xiaoqing Zhou

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1612868

2,831 views

Perspective

Published on 20 Aug 2025

Ethical dimensions and societal implications: ensuring the social responsibility of CRISPR technology

in Genome Editing in Human Health and Disease

Irfan Biswas

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1593172

3,339 views

Brief Research Report

Published on 23 Jul 2025

CRISPR-Cas9 editing of TNFAIP3 variants in salivary gland epithelial cells to study Sjögren’s disease pathogenesis

in Genome Editing in Human Health and Disease

Subhashis Ghosh
Qisheng Tu
Zoe Xiaofang Zhu
Sreelakshmi Panginikkod
Jake Jinkun Chen

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1625393

1,300 views

Original Research

Published on 30 Apr 2025

Efficient GBA1 editing via HDR with ssODNs by outcompeting pseudogene-mediated gene conversion upon CRISPR/Cas9 cleavage

in Genome Editing in Human Health and Disease

Joseph S. Lagas
Monica F. Sentmanat
Xiaoxia Cui

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1581743

2,928 views

Original Research

Published on 04 Apr 2025

Mapping the therapeutic landscape of CRISPR-Cas9 for combating age-related diseases

in Genome Editing in Human Health and Disease

Qiyu He
Yida Wang
Zhimin Tan
Xian Zhang
Chao Yu
Xiaoqin Jiang

Frontiers in Genome Editing

doi 10.3389/fgeed.2025.1558432

3,580 views
2 citations

Review

Published on 12 Dec 2024

Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine

in Genome Editing in Human Health and Disease

Sarkar Sardar Azeez
Rahin Shareef Hamad
Bahra Kakamin Hamad
Mudhir Sabir Shekha
Peter Bergsten

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1509924

21,267 views
16 citations

Original Research

Published on 16 Oct 2024

Beyond the traditional distinctions of genome editing: evaluating a vulnerability framework

in Genome Editing in Human Health and Disease

Ioanna Angelioudaki
Ana Ruxandra Badea
Martina Bodo
Daniel Fernández-Soto
Emmanouela Sevasti Karyampa
Adam Kokkinakis
Nikolaos Kolisis
Xenia Kominea
Sandra Ozáez Armijos
Simon Vogel

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1426228

3,371 views

Review

Published on 09 Oct 2024

The potential of HBV cure: an overview of CRISPR-mediated HBV gene disruption

in Genome Editing in Human Health and Disease

Zhi Q. Yao
Madison B. Schank
Juan Zhao
Mohamed El Gazzar
Ling Wang
Yi Zhang
Addison C. Hill
Puja Banik
Jaeden S. Pyburn
Jonathan P. Moorman

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1467449

6,576 views
5 citations

Review

Published on 23 Aug 2024

In vivo liver targeted genome editing as therapeutic approach: progresses and challenges

in Genome Editing in Human Health and Disease

Chiara Simoni
Elena Barbon
Andrés F. Muro
Alessio Cantore

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1458037

6,579 views
5 citations

Original Research

Published on 28 May 2024

CRISPR-Cas9 immune-evasive hESCs are rejected following transplantation into immunocompetent mice

in Genome Editing in Human Health and Disease

Henriette Reventlow Frederiksen
Alexandra Glantz
Kåre Kryger Vøls
Søren Skov
Pernille Tveden-Nyborg
Kristine Freude
Ulrik Doehn

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1403395

3,764 views
2 citations

Editorial

Published on 20 Mar 2024

Editorial: Prevention of viral diseases by gene targeting

in Genome Editing in Human Health and Disease

Fan Luo
Qiankun Wang
Shuliang Chen

Frontiers in Genome Editing

doi 10.3389/fgeed.2024.1395468

2,660 views
1 citation