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CASE REPORT article

Front. Glob. Women’s Health

Sec. Sex and Gender Differences in Disease

Volume 6 - 2025 | doi: 10.3389/fgwh.2025.1588553

Case Report: Ischemic Stroke in a Young Transgender Woman Due to Unsupervised Estrogen Therapy

Provisionally accepted
Lucas Blanco InsaurraldeLucas Blanco Insaurralde1,2*Andressa Camilo OliveiraAndressa Camilo Oliveira1,2Anny Gabriela Marçal de Carvalho AraújoAnny Gabriela Marçal de Carvalho Araújo1,2Maria Luiza Ferri CuryMaria Luiza Ferri Cury3Isabela Carvalho FlorêncioIsabela Carvalho Florêncio4Amanda BoutrikAmanda Boutrik1,2Franciely KimFranciely Kim1,2Egidi Mayara Firmino SilvaEgidi Mayara Firmino Silva1Luana Karen SantosLuana Karen Santos4Renata Gratão RezendeRenata Gratão Rezende4Rodolfo Antônio CoronaRodolfo Antônio Corona4Gabriel Pereira BragaGabriel Pereira Braga2,4
  • 1Federal University of Mato Grosso do Sul, Campo Grande, Brazil
  • 2Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil
  • 3Beneficent Society of Campo Grande Santa Casa, Campo Grande, Mato Grosso do Sul, Brazil
  • 4Universitary Hospital Maria Aparecida Pedrossian (HUMAP), Campo Grande, Mato Grosso do Sul, Brazil

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traditional risk factors for stroke, reinforcing the suspicion of estrogen's role in the event. Studies suggest that supervised hormone therapy carries a lower risk of complications compared to indiscriminate use. Nonetheless, there are still gaps in the literature regarding the correlation between HT and stroke in transgender individuals.This case highlights the risks of inappropriate use of gender-affirming hormone therapy and the need for rigorous medical supervision. Given the growing access to this treatment, continuous monitoring is essential to minimize complications. Further research is needed to establish safer guidelines for the use of hormone therapy in the transgender population.

Keywords: Stroke, Transgender health, hormone therapy, estrogen, cerebrovascular risk, ischemic stroke

Received: 11 Mar 2025; Accepted: 04 Jul 2025.

Copyright: © 2025 Insaurralde, Oliveira, Araújo, Cury, Florêncio, Boutrik, Kim, Silva, Santos, Rezende, Corona and Braga. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Lucas Blanco Insaurralde, Federal University of Mato Grosso do Sul, Campo Grande, Brazil

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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