CASE REPORT article
Front. Hum. Neurosci.
Sec. Brain Health and Clinical Neuroscience
Volume 19 - 2025 | doi: 10.3389/fnhum.2025.1638834
This article is part of the Research TopicAdvancing personalized diagnosis and treatment in Parkinson's Disease: Integrating biomarkers, neuroimaging, and artificial intelligenceView all 14 articles
A case report: Combined posterior subthalamic area and globus pallidus internus deep brain stimulation in Parkinson's disease
Provisionally accepted
- 1The Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
- 2NHC Key Lab of Drug Addiction Medicine (Kunming Medical University), Kunming, Yunnan, China
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Deep brain stimulation (DBS) is a primary surgical treatment for advanced Parkinson's disease (PD). The globus pallidus interna (GPi) is a key target for this procedure. The posterior subthalamic area (PSA) serves as an effective target for tremor-dominant Parkinson's disease. However, it is less commonly utilized in conventional DBS surgery compared to the subthalamic nucleus (STN) or the ventral intermediate nucleus (VIM). There is currently no clinical research on the combined DBS surgery targeting both the PSA and the GPi, which is why we have conducted this study.We introduced a case of a patient with advanced PD. Due to the patient's primary manifestations of right-sided tremor and left-sided rigidity, along with significant dyskinesia on the left side, DBS implantation was performed in the left hemisphere targeting the PSA and in the right hemisphere targeting the GPi. The patient's UPDRS-III score decreased from 73 to 46 postoperatively, showing an improvement of approximately 36.99%, while the H-Y stage improved from stage 4 to 2.5, representing a 37.5% improvement. During the 6-month postoperative follow-up, the patient's PD symptoms were effectively controlled, with no significant adverse effects.When advanced PD patients present with asymmetric and variable motor symptoms, combined DBS stimulation targeting both the GPi and the PSA is a viable treatment option.
Keywords: different targets, Deep Brain Stimulation, Posterior subthalamic area, globus pallidus internus, Parkinson's disease
Received: 31 May 2025; Accepted: 11 Jul 2025.
Copyright: © 2025 Deng, Hong, Yuan and Geng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xin Geng, The Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
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