ORIGINAL RESEARCH article
Front. Hum. Neurosci.
Sec. Motor Neuroscience
Volume 19 - 2025 | doi: 10.3389/fnhum.2025.1651309
The effect of neuro-enhancement technology on proprioception in patients with Anterior cruciate ligament reconstruction
Provisionally accepted
- 1Binzhou Medical University-Yantai Campus, Yantai, China
- 2Shandong Provincial Third Hospital, Jinan, China
- 3Binzhou Medical University Hospital, Binzhou, China
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Objective: To investigate whether the neural augmentation technique can induce improvement of proprioceptive performance in Anterior cruciate ligament reconstruction (ACLR) patients. Methods: Forty ACLR patients were recruited and randomly assigned to receive either active prefrontal cortex-targeted repetitive transcranial magnetic stimulation (rTMS) or sham stimulation (20 cases per group). All participants underwent the allocated intervention (active or sham rTMS over the prefrontal cortex) and completed standardized balance and proprioceptive assessments both pre-and post-intervention to evaluate the neuromodulatory effects on proprioceptive function in ACLR patients. The alpha level for statistical significance was set at ρ ≤0.05 a priori. Results: In the rTMS group, the Center of Pressure Area (COPA) and the Center of Pressure Sway (COPS) of the injured limb were significantly reduced before and after repeated transcranial magnetic stimulation (P=0.002), and the 30° positional sensory stimulation was significantly improved compared with the pre-stimulation period (P=0.012). Conclusion: Neuro-enhancement technology can improve the proprioceptive performance of ACLR patients and thus improve their motor ability.
Keywords: Anterior Cruciate Ligament Reconstruction, Proprioception, repetitive transcranial magnetic stimulation, Balance control, joint position sense
Received: 21 Jun 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 Wu, Du, Zhang, Zhang, Sun, Mi and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Baobin Mi, Binzhou Medical University Hospital, Binzhou, China
Wei Li, Binzhou Medical University Hospital, Binzhou, China
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