ORIGINAL RESEARCH article
Front. Hum. Neurosci.
Sec. Cognitive Neuroscience
This article is part of the Research TopicExploring the Impact of Music Interventions on Brain Function, Behavior, and HealthView all 11 articles
Spatial and temporal connectivity of brain resting-state fMRI during music-induced analgesia in fibromyalgia patients
Provisionally accepted
- 1Southwest University, Chongqing, China
- 2University of Wisconsin-Madison, Madison, United States
- 3Suzhou University of Science and Technology, Suzhou, China
- 4Fujian Normal University, Fuzhou, China
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Music-induced analgesia (MIA) has significant clinical value for patients with fibromyalgia (FM) and serves as a key model for understanding the complex neural mechanisms underlying the effects of music on physical and mental states. The current study examined the neural correlates of MIA in FM patients using resting-state functional magnetic resonance imaging (RS-fMRI) with fractional amplitude of low frequency fluctuations (fALFF), regional homogeneity (ReHo) and degree centrality (DC) measures. Results showed that following music listening, FM patients exhibited significant reduction in evaluation of pain intensity, and also exhibited significant RS-fMRI changes in fALFF, ReHo and DC in the frontal, occipital, central areas, limbic system and cerebellum. Additionally, correlations were found between behavioral task and fALFF or ReHo measure. These findings suggest the effectiveness of music's pain regulation function and provide spatial and temporal fMRI evidences for understanding the neural mechanism underlying MIA.
Keywords: Degree centrality, Fibromyalgia, fractional amplitude of low frequency fluctuations, music-induced analgesia, regional homogeneity
Received: 02 May 2025; Accepted: 05 Jan 2026.
Copyright: © 2026 Liu, Hosseini, Zheng, Liu, Sun and Hou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiancheng Hou
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