Frontiers in Medical Technology | Pharmaceutical Innovation

Original Research

Accepted on 02 Sep 2025

Orodispersible Films Containing Chestnut Shell Phenolics for Buccal Delivery: A Preclinical Approach for Oral Mucositis Prevention

in Pharmaceutical Innovation

Ana Sofia Ferreira
Ana Margarida Silva
Catarina Macedo
Emily Laveriano
Julián Lozano-Castellón
Rosa Maria Lamuela Raventós
Jaroslava Švarc-Gajíc
Paulo Costa
Cristina Delerue-Matos
Francisca Rodrigues

Frontiers in Medical Technology

doi 10.3389/fmedt.2025.1675082

118 views

Original Research

Published on 01 Sep 2025

Exploration of the antiviral mechanism of gypsum-licorice compatibility pairing in Ma-Xing-Shi-Gan decoction from the perspective of metal-organic supramolecular interactions

in Pharmaceutical Innovation

Chang Lu
Ying Ma
Haoyu Zhao
Yu Zheng
Qun Zhao
Lili Lin
XiuZhen Chen
Linwei Chen
Gang Li
Rui Chen

Frontiers in Medical Technology

doi 10.3389/fmedt.2025.1651390

537 views

Perspective

Accepted on 25 Aug 2025

Feasibility analysis of automated cleaning in biopharmaceutical production by using cleaning-in-place concepts from food production

in Pharmaceutical Innovation

Ferdinand Groten
Chris Henze
Matthias Jopppa
Laura Herbst
Marc Mauermann
Bastian Nießing
Robert Schmitt

Frontiers in Medical Technology

doi 10.3389/fmedt.2025.1540779

207 views

Original Research

Published on 14 Jul 2025

A plant secretory sequence enhances immunogenicity of electroporated COVID-19 DNA vaccines

in Pharmaceutical Innovation

Olivia Costantina Demurtas
Flavia Novelli
Doriana Triggiani
Caterina Merla
Emanuela Pasquali
Silvia Massa
Rosella Franconi
Claudio Pioli

Frontiers in Medical Technology

doi 10.3389/fmedt.2025.1597179

1,029 views

Original Research

Published on 06 Feb 2025

Bioanalytical method development, in-vivo pharmacokinetic evaluation, ex-vivo platelet aggregation inhibition activity of a novel solid dispersion formulation of ticagrelor

in Pharmaceutical Innovation

Abhishek Srivastava
Simrata Bedi
Abhishesh Kumar Mehata
Datta Maroti Pawde
Ketan Vinayakrao Hatware
Mohammad Ahmad Khan
M. S. Muthu
Uma Bhandari

Frontiers in Medical Technology

doi 10.3389/fmedt.2025.1499189

1,672 views

Review

Published on 21 Nov 2024

Cost-effective track and trace technology for poor-quality chemotherapeutic pharmaceuticals in resource-limited countries: a review of the Chemotherapeutic Paper Analytical Device

in Pharmaceutical Innovation

Minichil Chanie Worku
Liknew Workie Limenh
Biset Asrade Mekonnen
Yeniewa Kerie Anagaw

Frontiers in Medical Technology

doi 10.3389/fmedt.2024.1436614

1,413 views

Review

Published on 23 Jan 2024

The use of nanoparticles in the treatment of infectious diseases and cancer, dental applications and tissue regeneration: a review

in Pharmaceutical Innovation

Ali Sobhani-Nasab
Hamid Reza Banafshe
Amir Atapour
Mahmood Khaksary Mahabady
Maryam Akbari
Abdolreza Daraei
Yaser Mansoori
Amin Moradi Hasan-Abad

Frontiers in Medical Technology

doi 10.3389/fmedt.2023.1330007

6,385 views
5 citations

Editorial

Published on 12 May 2023

Editorial: Innovative approaches in drug discovery and development

in Pharmaceutical Innovation

Qasem Ramadan
Diego Romano Perinelli
Laura Orian
Sara Baratchi

Frontiers in Medical Technology

doi 10.3389/fmedt.2023.1206088

4,067 views
4 citations

Methods

Published on 26 Jan 2023

Novel and efficient method for the reconstruction of adenoviruses through isothermal assembly and its potential applications

in Pharmaceutical Innovation

Ke Wen
Matthew D. Resch
Ryan Mazboudi
Hannah Mulhall Maasz
Jose M. Galarza

Frontiers in Medical Technology

doi 10.3389/fmedt.2023.1095198

3,505 views
3 citations

Opinion

Published on 16 Dec 2022

A proof-of-concept study poised to remodel the drug development process

in Pharmaceutical Innovation

Zaher Nahle

Frontiers in Medical Technology

doi 10.3389/fmedt.2022.1053588

6,726 views
7 citations

Review

Published on 21 Oct 2022

Sourcing cells for in vitro models of human vascular barriers of inflammation

in Pharmaceutical Innovation

Molly C. McCloskey
Victor Z. Zhang
S. Danial Ahmad
Samuel Walker
Samantha S. Romanick
Hani A. Awad
James L. McGrath

Frontiers in Medical Technology

doi 10.3389/fmedt.2022.979768

18,259 views
5 citations

Original Research

Published on 05 Oct 2022

SARS-CoV-2 variants impact RBD conformational dynamics and ACE2 accessibility

in Pharmaceutical Innovation

Mariana Valério
Luís Borges-Araújo
Manuel N. Melo
Diana Lousa
Cláudio M. Soares

Frontiers in Medical Technology

doi 10.3389/fmedt.2022.1009451

6,818 views
23 citations

Perspective

Published on 01 Aug 2022

Improving treatment for acute ischemic stroke—Clot busting innovation in the pipeline

in Pharmaceutical Innovation

Joanna Shu Ting Liu
Yiran Ding
Simone Schoenwaelder
Xuyu Liu

Frontiers in Medical Technology

doi 10.3389/fmedt.2022.946367

6,199 views
9 citations

Original Research

Published on 15 Jul 2022

Multiphysics pharmacokinetic model for targeted nanoparticles

in Pharmaceutical Innovation

Emma M. Glass
Sahil Kulkarni
Christina Eng
Shurui Feng
Avishi Malaviya
Ravi Radhakrishnan

Frontiers in Medical Technology

doi 10.3389/fmedt.2022.934015

4,463 views
6 citations

Original Research

Published on 04 Apr 2022

Effect of Patent Expiry on the Performance of Innovator Multinational Pharmaceutical Companies in a Low Middle Income Country

in Pharmaceutical Innovation

Farrukh Khalil
Joseph Odhiambo Onyango

Frontiers in Medical Technology

doi 10.3389/fmedt.2022.783460

13,026 views
3 citations

Original Research

Published on 28 Mar 2022

Identification of 1, 2, 4-Triazine and Its Derivatives Against Lanosterol 14-Demethylase (CYP51) Property of Candida albicans: Influence on the Development of New Antifungal Therapeutic Strategies

in Pharmaceutical Innovation

Abhishek Kumar Verma
Aarfah Majid
Md. Shahadat Hossain
SK. Faisal Ahmed
Mohammad Ashid
Ali Asger Bhojiya
Sudhir K. Upadhyay
Naveen Kumar Vishvakarma
Mudassir Alam

Frontiers in Medical Technology

doi 10.3389/fmedt.2022.845322

5,822 views
14 citations