ORIGINAL RESEARCH article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1493761
This article is part of the Research TopicCurrent Advances and Challenges in Neurocritical Care after Reperfusion Therapy: From Bench Work to Practical AspectsView all 5 articles
Association of Follow-up Neutrophil-Lymphocyte Ratio with Postoperative Pneumonia in Aneurysmal Subarachnoid Hemorrhage Patients after Endovascular Treatment: A Retrospective Analysis
Provisionally accepted
Xinyue Huang1Xiumei Guo1Wen Gao1Liming Guo1Hanlin Zheng1Zhigang Pan1Qingxin Lin1Shuni Zheng1Chuhan Ke1Feng Zheng1*Zhen Qi2*
Feng Zheng1*- 1The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
- 2Jinjiang Municipal Hospital, Quanzhou, Fujian Province, China
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Research on the relationship between dynamic neutrophil-to-lymphocyte ratio (NLR)-measured at different time points around endovascular treatment-and the occurrence of postoperative pneumonia (POP) in patients with aneurysmal subarachnoid hemorrhage (aSAH) is still relatively scarce. This study aims to explore the association between dynamic NLR and the incidence of POP in patients with aSAH undergoing endovascular therapy.Methods: This study included patients with aSAH who underwent endovascular treatment between January 2019 and April 2023. The follow-up endpoint was the presence of POP at 30 days postoperatively. Logistic regression analysis was conducted using POP as the dependent variable.The NLR was calculated at admission (NLR1), 24 h after endovascular treatment (NLR2), and 3-7 days after endovascular treatment (NLR3). Four prediction models were constructed: Model 1 (variables with p<0.05, except for the NLR), Model 2 (Model 1 plus NLR1), Model 3 (Model 1 plus NLR2), and Model 4 (Model 1 plus NLR3).Results: Among the 154 patients with aSAH, POP occurred in 101 (65.6%) patients. Higher NLRs at admission (odds ratio [OR]=1.08; 95% confidence interval [CI]: 1.02, 1.16; p=0.019), 24 h postoperatively (OR=1.14; 95% CI= 1.05, 1.25; p=0.005) and 3-7 days postoperatively (OR=1.17; 95% CI= 1.02, 1.38; p=0.04) were associated with the occurrence of POP.Follow-up NLR may be associated with POP in patients with aSAH treated endovascularly. Elevated NLR at admission, 24 h postoperatively, and 3-7 days postoperatively correlated with a high risk for POP.
Keywords: Neutrophil-lymphocyte ratio, aneurysmal subarachnoid Hemorrhage, Postoperative pneumonia, endovascular treatment, Predict
Received: 11 Sep 2024; Accepted: 20 Jun 2025.
Copyright: © 2025 Huang, Guo, Gao, Guo, Zheng, Pan, Lin, Zheng, Ke, Zheng, Qi and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Feng Zheng, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
Zhen Qi, Jinjiang Municipal Hospital, Quanzhou, Fujian Province, China
Feng Zheng, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
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