ORIGINAL RESEARCH article
Front. Med.
Sec. Obstetrics and Gynecology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1498694
Epidemiological Analysis of Maternal Hypertensive Disorders of Pregnancy
Provisionally accepted
AiJuan Yuan*
Hui Huang- Ningbo University Affiliated People's Hospital, Ningbo, China
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We aimed to provide a comprehensive overview of the epidemiology of hypertensive disorders of pregnancy (HDP) from 1990 to 2021, examining incidence and trends across national, continental, and global levels.Methods: HDP were assessed by calculating the age-standardized incidence rate (ASIR) and age-standardized disability-adjusted life years (DALYs) rate, as well as the Estimated Annual Percentage Change (EAPC) for each region and country. The Global Burden of Disease (GBD) 2021Study age-standardized rates, which were obtained from 204 countries and territories, were used to analyze the burden based on age and sociodemographic index (SDI).The global burden of HDP has changed substantially between 1990 and 2021. The total number of DALYs was 2.47 million (95% UI: 2.08 to 2.96), and ASIR was 461.94 per 100,000 in 2021. The estimated annual percentage change (EAPC) for the DALY rate was -2.10 (95% CI: -2.15 to -2.04), and the EAPC for ASIR was -0.51 (95% CI: -0.56 to -0.45). The Russian Federation, Romania, and Georgia had the greatest increases in ASIR over time. Guam, American Samoa, and the United Republic of Tanzania had the highest EAPC for the DALY rate. Analysis by age showed that maternal hypertensive disorders caused the greatest DALYs among women aged 25-39 years and the fewest DALYs among those aged 50-54 years. There was a positive relationship between ASIR and SDI. The same trend was observed for the DALY rate.Conclusions: Our findings revealed that DALY rates and incidence rates of HDP decreased in most regions, except in areas with lower sociodemographic indices, such as the Caribbean. The greatest burden of HDP was observed among women aged 25 to 39 years. These results underscore the need for targeted interventions in low-SDI regions and highlight the importance of addressing HDP as a key component of maternal health initiatives globally.
Keywords: maternal hypertensive disorders, Incidence, estimated annual percentage change, Disability-adjusted life years, Global burden of disease
Received: 09 Oct 2024; Accepted: 08 Jul 2025.
Copyright: © 2025 Yuan and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: AiJuan Yuan, Ningbo University Affiliated People's Hospital, Ningbo, China
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