CASE REPORT article
Front. Med.
Sec. Obstetrics and Gynecology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1503083
Histologically Confirmed High-grade Cervical Intraepithelial Neoplasia Successfully Treated With Topical Paiteling: A Two-case Report
Provisionally accepted
- 1the first affiliated hospital of Shenzhen University, Shenzhen, China
- 2Shenzhen Luohu People's Hospital, Shenzhen, China
- 3Shenzhen Hospital, Peking University, Shenzhen, Beijing Municipality, China
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Background: High-grade cervical intraepithelial neoplasia (HSIL) threatens fertility-aged women worldwide. Surgical excision remains standard but may compromise future pregnancy. Paiteling, a multi-herbal topical preparation, has shown in vitro anti-HPV activity, yet clinical evidence is scant. Case Presentation: Two reproductive-aged women with biopsy-proven HSIL refused loop electrosurgical excision. Biopsy slides were re-reviewed independently with p16 and Ki-67 immunostaining. Case 1 was CIN II and Case 2 was CIN III. Both patients received topical Paiteling (0.5 mL/lesion, three times weekly) plus 1 % vaginal douche for 10 weeks. Intervention & Outcome: Lesions regressed completely within the treatment course. HPV-DNA testing confirmed HPV clearance by week 12. Follow-up colposcopy, cytology and directed biopsy remained negative at 12 months (Case 1) and 16 months (Case 2). Only mild transient vaginal burning occurred. Conclusion: Topical Paiteling achieved histological and virological remission in two pathologically confirmed HSIL cases that declined excisional surgery. The findings suggest a fertility-preserving option worth systematic evaluation in prospective trials.
Keywords: High-grade cervical intraepithelial neoplasia, HSIL, Topical Paiteling, Human papillomavirus, Fertility-preserving therapy
Received: 17 Mar 2025; Accepted: 22 Sep 2025.
Copyright: © 2025 Li, Chen, Hou, Yang, Yu and Guan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jing Li, kriklee@connect.hku.hk
Zhiying Yu, lizheyzy@163.com
Songqing Guan, lovecc138@163.com
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