STUDY PROTOCOL article
Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1505093
This article is part of the Research TopicFrailty- and Age-Associated Diseases: Possibilities For Intervention (Volume 2)View all 10 articles
Protocol for a Systematic Review of Sarcopenia in Older Adults with Type 2 Diabetes Mellitus and Its Association with Increased Risk of Mortality
Provisionally accepted
- 1Ramathibodi Nursing School, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Ratchathewi, Thailand
- 2Ramathibodi School of Nursing, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
- 3University of Washington, Seattle, Washington, United States
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Background: Sarcopenia and type 2 diabetes mellitus (T2DM) are prevalent health conditions that significantly impact mortality risk, particularly among older adults. This study aims to examine the association between sarcopenia and all-cause mortality in older adults with T2DM. It seeks to evaluate whether this relationship varies by population characteristics, sarcopenia definitions, and follow-up duration.Methods: We will conduct a comprehensive literature search using databases such as PubMed, Scopus, CINAHL, and Embase to identify studies exploring the relationship between sarcopenia and all-cause mortality in older adults with T2DM from January 1, 2014, to September 1, 2024. Two authors will independently screen all eligible clinical studies. Statistical analyses will be conducted using JBI SUMARI software.Results: Preliminary findings will indicate the overall prevalence and mortality rate among older adults with sarcopenia and T2DM. By consolidating findings from diverse studies, this meta-analysis will provide clearer insights into how sarcopenia and T2DM interact to affect mortality risk.Conclusion: Understanding the relationship between sarcopenia and T2DM is crucial leading to developing effective interventions to reduce mortality risk and improve the quality of life in older adults. Addressing this important research gap will contribute to better healthcare practices and outcomes.
Keywords: Sarcopenia, type 2 diabetes mellitus, mortality risk, Systematic review, protocol, Meta-analysis
Received: 02 Oct 2024; Accepted: 21 Jul 2025.
Copyright: © 2025 Whaikid, Piaseu and Souza. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Noppawan Piaseu, Ramathibodi Nursing School, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Ratchathewi, Thailand
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