STUDY PROTOCOL article
Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1508731
This article is part of the Research TopicUrban AgingView all 3 articles
The Effect of Heat-Sensitive Moxibustion in the Elderly with Nocturia: Protocol for a Randomized Controlled Trial
Provisionally accepted
- 1The Second Affiliated Hospital, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
- 2The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China
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Background: Nocturia is a common and bothersome symptom in the elderly population, significantly impacting their quality of sleep and overall well-being.Heat-Sensitive moxibustion (HSM) is effective for elderly people with nocturia, but its efficacy has not been scientifically proven. This randomized controlled trial is designed to determine the efficacy and safety of HSM in the elderly with Nocturia.Method: This study is designed as a randomized, single-blind clinical trial, focusing on a population of 110 patients aged 60 and above who suffer from nonspecific nocturia lasting for at least one month. Patients in the intervention arm are scheduled for 2 cycles of HSM, while patients in the control group will undergo the same cycle of convenient treatment. To ensure objectivity, assessors and investigators will remain blinded to the randomization process. The primary outcome of this study is the reduction in the frequency of nocturia. Additionally, several secondary outcomes will be evaluated, including sleep quality, quality of life scores, the efficacy of traditional Chinese medicine (TCM) syndrome, and changes in blood biomarkers Arginine vasopressin (AVP) and Atrial natriuretic peptide (ANP). These assessments will be conducted at baseline, post-intervention and at the 2-month follow-up to comprehensively evaluate the effectiveness and safety of HSM.Discussion: In this study, we aim to quantitatively analyse the therapeutic effect and safety of HSM on nocturia in the elderly, clarify the amount of moxibustion, the distribution pattern of heat-sensitized acupoints, the frequency of heat-sensitized acupoints, and the moxibustion sensation for the treatment of senile nocturia, which can bring insights into future clinical treatments.
Keywords: Nocturia, Elderly, Heat-Sensitive Moxibustion, Traditional Chinese Medicine, Clinical Trial Design Abbreviation: HSM, Heat-Sensitive Moxibustion, Avp, arginine vasopressin, ANP, Atrial natriuretic peptide, CT: Convenient Treatment, ITT: Intention-to-treat
Received: 09 Oct 2024; Accepted: 16 Jun 2025.
Copyright: © 2025 Geng, Ma, Lin, Lin, Wen, Ruan, Mo, Shuang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xintong Ma, The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China
Na Liu, The Second Affiliated Hospital, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510000, China
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