REVIEW article
Front. Med.
Sec. Hepatobiliary Diseases
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1525526
This article is part of the Research TopicBridging the Gap: Current Clinical Practices for Metabolic Dysfunction-Associated Steatotic Liver DiseaseView all 6 articles
Mapping and visualization of global research progress on autophagy in metabolic dysfunction-associated steatotic liver disease and metabolic syndrome: A Bibliometric Analysis (2009-2024)
Provisionally accepted
- 1Shenzhen Pingle Orthopedic Hospital, Shenzhen, China
- 2School of Public Health, Sun Yat-sen University, Shenzhen Campus, Shenzhen, China
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Objective: This study aimed to delineate the current trends and hotspots in autophagy research related to metabolic syndrome (MetS) and metabolic dysfunction-associated steatotic liver disease (MASLD), with the aim of guiding future investigations in this area. Methods: This study extracted research on autophagy in MetS and MASLD from the Web of Science Core Collection (WoSCC) database. Review articles were systematically excluded to focus on original research contributions. A bibliometric analysis and visualization were conducted using VOSviewer 1.6.20, CiteSpace 6.3.R1, and R 4.3.3.Results: The study included 1,114 articles from 1220 institutions across 42 countries/regions, demonstrating a significant increase in research output from 2009 to 2024. China led with 506 publications, followed by the USA and Korea. The Egyptian Knowledge Bank constitutes a consortium of institutions operating within the national research framework, with one institution designated as the primary publishing entity. Notably, the journal Nature has emerged as the most frequently cited publication. Singh Rajat received the highest number of citations (3,610), while Marycz, Krzysztof was the most prolific author. The most cited article, published in 2009, was titled "Autophagy regulates lipid metabolism." Keyword trends have shifted from earlier topics such as "phosphorylation" and "gene-expression" to more recent terms like "lipid accumulation" and "mitophagy." Burst keyword analysis indicated that "liver fibrosis," "modulation," gut microbiota," and "lipotoxicity" have emerged as significant topics. Conclusions: This study has elucidated the protective role of autophagy in MASLD and MetS. Future research is anticipated to concentrate on the activation of autophagy in the context of natural product drug discovery, the exploration of underlying molecular mechanisms, the regulation of fatty acid metabolism, and the development of functional nutritional supplements, among other relevant areas.
Keywords: autophagy1, non-alcoholic fatty liver disease2, Metabolic syndrome3, bibliometric analysis4, VOSviewer5, CiteSpace6
Received: 09 Nov 2024; Accepted: 09 Jun 2025.
Copyright: © 2025 Liu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiang Li, School of Public Health, Sun Yat-sen University, Shenzhen Campus, Shenzhen, China
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