ORIGINAL RESEARCH article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1525973
This article is part of the Research TopicManagement of Spine Pathologies in Geriatric PatientsView all 8 articles
Safety and Efficacy of Ciprofol for General Anesthesia Induction in Elderly Patients Undergoing Lumbar Surgery
Provisionally accepted
- 1Department of Anesthesiology, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi Zhuang Region, China
- 2Department of Anesthesiology, Liuzhou People's Hospital, Liuzhou, Guangxi Zhuang Region, China
- 3Liuzhou Perioperative Neuroprotection Engineering Technology Research Center, Liuzhou, China
- 4Liuzhou Key Laboratory of Anesthesia and Perioperative Neuroprotection, Liuzhou, China
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Objective: This study aimed to evaluate the safety and efficacy of ciprofol for anesthesia induction in elderly patients undergoing lumbar surgery.Methods: Sixty patients aged 65-80 years scheduled for elective lumbar surgery under general anesthesia were randomly divided into two groups (n=30 each): ciprofol group and propofol group. The ciprofol group received intravenous ciprofol 0.4 mg/kg combined with sufentanil 0.4 μg/kg, while the propofol group received propofol 2 mg/kg combined with sufentanil 0.4 μg/kg for anesthesia induction.Hemodynamic parameters including BIS, SBP, DBP, MAP, cardiac index, pulse pressure variation, systemic vascular resistance index, and stroke volume index were recorded during induction. Time to achieve target anesthetic depth was also evaluated.Adverse events including movement, lacrimation, hypotension, hypertension, bradycardia, and coughing during induction were documented.Results: Both groups showed comparable time to achieve target anesthetic depth and similar trends in hemodynamic changes. However, the ciprofol group demonstrated significantly lower incidence of hypotension compared to the propofol group (20% vs. 63%, P<0.05), with reduced norepinephrine consumption. The incidence of other adverse events showed no significant differences between groups.Ciprofol demonstrates comparable safety and efficacy to propofol for anesthesia induction in elderly patients undergoing lumbar surgery, with superior hemodynamic stability, supporting its clinical application in geriatric lumbar surgery.
Keywords: Ciprofol, general anesthesia, Anesthesia induction, geriatric lumbar surgery, Elderly
Received: 11 Nov 2024; Accepted: 09 Jun 2025.
Copyright: © 2025 Yao, Wei, Zhong, Liu, Zhang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yanhua Chen, Department of Anesthesiology, First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Region, China
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