ORIGINAL RESEARCH article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1541519
This article is part of the Research TopicInnovative Monitoring and Management of Perioperative Complications in Cardiac SurgeryView all 10 articles
Decreased vasoregulatory dysfunction associated with intra-operative hemoadsorption treatment is related to mitigated posttransplant procalcitonin rather than cytokine or complement response
Provisionally accepted
Hajna KatonaAdam SolteszEniko KovacsZsofia Szakal-TothEszter TamaskaKristof RaczTamás RadovitsAttila FinthaKrisztián KovácsLisa Hurler
Zoltán Prohászka
Bela Merkely
Endre Nemeth*- Semmelweis University, Budapest, Hungary
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The aim of this study was to investigate the modulatory effect of intraoperative hemoadsorption (HA) versus standard care on the perioperative inflammatory profile of patients undergoing orthotopic heart transplantation (OHT) and its correlation with the severity of posttransplant vasoregulatory dysfunction.In this secondary analysis, data from NCT03145441, a prospective, single-center, openlabel, randomized controlled trial were used.Results: Patients in the HA group had a lower median vasopressor score, rate of severe vasoregulatory dysfunction (vasopressor score: 19.
Keywords: complement system1, cytokines2, CytoSorb3, Hemoadsorption4, heart transplantation5, procalcitonin6, Vasopressor score7
Received: 07 Dec 2024; Accepted: 29 Jul 2025.
Copyright: © 2025 Katona, Soltesz, Kovacs, Szakal-Toth, Tamaska, Racz, Radovits, Fintha, Kovács, Hurler, Prohászka, Merkely and Nemeth. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Endre Nemeth, Semmelweis University, Budapest, Hungary
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