ORIGINAL RESEARCH article
Front. Med.
Sec. Obstetrics and Gynecology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1544679
Clinical factors associated with developmental delay in placental abruption
Provisionally accepted
- School of Medicine, CHA Univeristy, Seongnam, Republic of Korea
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Background: This study aimed to investigate the association between clinical characteristics and neonatal developmental delay in women with placental abruption (PA).We retrospectively reviewed obstetric characteristics and perinatal outcomes of singleton pregnancies complicated by PA who were healthy before pregnancy between 2010 and 2021. Neuromotor development was evaluated using Bayley Scales of Infant and Toddler Development, Third Edition, and/or Gross Motor Function Measure. Clinical characteristics were compared between offspring with and without developmental delay to identify associated risk factors.Results: Among 9,374 deliveries, 188 cases (2.0%) were diagnosed with PA, and 33 infants exhibited developmental delay. Maternal demographics, including age, body mass index, nulliparity, and history of preterm birth, did not differ significantly between groups. Prenatal ultrasound suspected PA in 16.4% of cases in the developmental delay group and 18.2% in the no-delay group. However, a longer interval between diagnosis and delivery (aOR = 9.82; 95% CI, 1.25-77.24; P = 0.030) and delivery before 32 weeks' gestation (aOR = 19.65; 95% CI, 1.46-264.40; P = 0.025) were significantly associated with developmental delay.Ultrasound findings suggestive of PA were not associated with developmental delay in offspring. However, a prolonged diagnosis-to-delivery interval and extreme prematurity were significant risk factors. These findings underscore the limitations of ultrasound in detecting clinically significant PA and highlight the importance of timely clinical decision-making. Further research is warranted to improve diagnostic strategies for PA.
Keywords: Placental abruption, Placenta, Obstetric hemorrhage, developmental delay, postnatal long-term outcomes
Received: 13 Dec 2024; Accepted: 13 Jun 2025.
Copyright: © 2025 Joo, Kim, Ryu, Jung, Ahn and Lee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ji Yeon Lee, School of Medicine, CHA Univeristy, Seongnam, Republic of Korea
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