ORIGINAL RESEARCH article
Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1545344
This article is part of the Research TopicInnovations and Advancements in the Management of Male Lower Urinary Tract Symptoms (LUTS)View all 3 articles
Association between lifestyle, multiple chronic conditions, mental health status and the severity of lower urinary tract symptoms/benign prostatic hyperplasia in Chinese elderly
Provisionally accepted
- 1Department of Urology, Jiangnan University Medical Center, Wuxi, China
- 2Wuxi School of Medicine, Jiangnan University, Wuxi, China
- 3Medical School of Nantong University, Nantong, China
- 4Department of Neurology, Jiangnan University Medical Center, Wuxi, China
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The etiology and pathogenesis of lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) are complex, and understanding of factors related to symptom severity can improve the disease prognosis. The aim of this study was to explore the association between LUTS/BPH severity and lifestyle, multiple chronic conditions (MCC), and mental health status in Chinese elderly individuals, and to provide a reference for developing comprehensive intervention measures.Method: A total of 806 patients aged 60 and above with LUTS/BPH were divided into mild and moderate-to-severe groups based on IPSS assessment. All participants completed data collection on general demographics, clinical characteristics, lifestyle factors, MCC, and mental health status (including anxiety, depression, and sleep quality). A binary logistic model was employed to investigate the influence of lifestyle, MCC, and mental health status on LUTS/BPH severity.The moderate-to-severe group had significantly higher rates of unhealthy lifestyle habits, MCC, and mental health problems compared to the mild group. After adjusting for confounders (such as age, disease duration, prostate volume, total prostate-specific antigen, C-reactive protein, post-voided residual urine, urea nitrogen, etc.), current smoking (OR=1.995, 95%CI:1.270-3.134), unhealthy dietary habits (OR=1.590, 95%CI: 1.059-2.386), and lack of active exercise (OR=1.996, 95%CI:1.274-3.127) were positively correlated with the severity of BPH/LUTS. Conversely, the absence of heart disease (OR=0.435, 95%CI:0.268-0.707), normal lipid profile (OR=0.587, 95%CI:0.354-0.973), no diabetes mellitus (OR=0.523, 95%CI:0.312-0.878), no depressive disorder (OR=0.447, 95%CI:0.204-0.979) and no sleep disorder (OR=0.494, 95%CI:0.322-0.758) were significantly negatively correlated with the severity of BPH/LUTS.The study revealed a strong correlation between the severity of LUTS/BPH and poor lifestyle, multiple chronic diseases, and mental health problems. Therefore, the prevention and treatment of LUTS/BPH should fully consider these factors.
Keywords: Lower Urinary Tract Symptoms, Benign prostatic hyperplasia, lifestyle, multiple chronic conditions, Mental Health, Geriatric medicine
Received: 14 Dec 2024; Accepted: 11 Jun 2025.
Copyright: © 2025 Wu, Zhang, Liu, Huang, Hua and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ye Hua, Department of Neurology, Jiangnan University Medical Center, Wuxi, China
Ninghan Feng, Department of Urology, Jiangnan University Medical Center, Wuxi, China
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