ORIGINAL RESEARCH article
Front. Med.
Sec. Nephrology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1546112
This article is part of the Research TopicOutcome of Sepsis and Prediction of Mortality Risk - Volume IIView all articles
Correlation between lactate/albumin ratio and 28-day mortality in sepsis-associated acute kidney injury patients
Provisionally accepted
- 1Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- 2Department of Hepatobiliary Surgery, Shaanxi Provincial People’s Hospital, Xi'an city, China
- 3Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, China
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The lactate/albumin ratio (LAR) was related to adverse outcomes in heart failure, myocardial infarction, and acute pancreatitis. However, it remains unevaluated whether LAR has prognosis significance in sepsis-associated acute kidney injury (SA-AKI) patients. Therefore, this research was performed to clarify the potential predictive utility of LAR for 28-day mortality in SA-AKI patients.Participants diagnosed with SA-AKI were selected from the Medical Information Mart for Intensive Care (MIMIC-IV) database and then placed into four groups in accordance with LAR quartiles. The endpoint was all-cause mortality within 28 days. The Kaplan-Meier curves were conducted to estimate the cumulative survival rates in the four groups. The correlation between LAR and the endpoint was elucidated by constructing Cox proportional hazards analysis, restricted cubic splines (RCS) and subgroup analysis.Of the 3895 patients with SA-AKI, and 58.59% were men. The mortality rate from all causes within 28 days was 28.55%. The Kaplan-Meier curves showed that participants having elevated LAR exhibited significantly decreased survival rates. Cox proportional hazards models showed that higher LAR were related to higher 28-day death rate in p<0.001). Additionally, RCS analyses revealed that LAR was non-linearly correlated with the risk of 28-day death.LAR was independently related to an elevated risk of mortality within 28 days in SA-AKI patients. More prospective researches are necessitated for further confirmation of these findings.
Keywords: Sepsis-associated acute kidney injury, Lactate/albumin ratio, Mortality, 28-day, MIMIC-IV
Received: 16 Dec 2024; Accepted: 13 May 2025.
Copyright: © 2025 He, Wang, Wei and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shifeng Yang, Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
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