REVIEW article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1546389
Association and Risk Factors Analysis of FeNO and CRP in Bronchial Asthma Combined with Obstructive Sleep Apnea (OSA)Association and risk factors analysis of FeNO and CRP with bronchial asthma combined with sleep apnea syndrome
Provisionally accepted
- 1Affiliated Hospital of Hebei University of Engineering, Handan, China
- 2Hebei university of engineering, Handan, China
- 3affiliated hospital neurosurgery Hebei University of engineerimg, Handan, China
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Bronchial asthma (BA) and obstructive sleep apnea (OSA)sleep apnea syndrome (SAS) are chronic disorders of the respiratory system; both diseases are widespread and can cause a decrease in the quality of life. The latter contrasts the airway inflammation and excessive reactivity that define BA, and the intermittent airway obstruction during sleep that defines OSASAS results in periods of hypoxemia and disruptive breathing. BA appears when children have OSASAS in addition to other disorders, including night ventilation, breathlessness, and sleep conflicts. Current studies have focused on inflammatory indicators such as the FeNO and CRP in these diseases. FeNO is a measure of eosinophilic airway inflammation, which is usually high in asthma. In, contrast, CRP is a measure of systemic inflammation that is usually high in both forms of asthma. This review paper will focus on FeNO and CRP in connection to the pathophysiology of BA and OSASAS with further descriptions of how these markers relate to inflammation in both disorders. The review also focuses on how these markers interlink in patients with both diseases and how FeNO and CRP can also reflect the severity of Formatted: Font: (Default) Times New Roman, 14 pt, Bold Formatted: Font: (Default) Times New Roman, 12 pt the disease and the effectiveness of the treatments being used. Finally, identifying the interaction between these markers might advance the identification and management of patients with both BA and OSASAS.
Keywords: Sleep apnea syndrome, bronchial asthma, Fractional exhaled nitric oxide, of inflammatory markers Obstructive Sleep Apneasleep apnea syndrome, fractional exhaled， nitric oxide, of inflammatory markers GWAS = Genome-Wide Association Studies
Received: 16 Dec 2024; Accepted: 26 May 2025.
Copyright: © 2025 Yan, Zhu and Peng Fei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhao Yan, Affiliated Hospital of Hebei University of Engineering, Handan, China
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