ORIGINAL RESEARCH article
Front. Med.
Sec. Precision Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1546533
This article is part of the Research TopicRe-visiting Risk Factors for Cardiometabolic Diseases: Towards a New Epidemiological FrontierView all 35 articles
Uric Acid to HDL Cholesterol Ratio (UHR) as a Novel Biomarker for Functional Myocardial Ischemia in Patients Without SMuRFs
Provisionally accepted
- 1Xi'an Jiaotong University, Xi'an, China
- 2Harbin Medical University, Harbin, Heilongjiang, China
- 3Yinghua Hospital, Harbin, China
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Objective: This study aims to explore the diagnostic efficacy of the uric acid to highdensity lipoprotein cholesterol ratio (UHR) as a biomarker for functional myocardial ischemia in the absence of standard modifiable cardiovascular risk factors (SMuRFs).Methods: Between January 2020 and June 2023, we conducted a retrospective analysis of 2,348 patients suspected of having coronary artery disease (CAD) who underwent computed tomography fractional flow reserve (CT-FFR) assessment. The patients were stratified into two groups based on their CT-FFR values: CT-FFR ≤ 0.8 and CT-FFR > 0.8. To account for differences in baseline characteristics between the two groups, propensity score matching was applied in a 1:1 ratio, resulting in 1,174 patients per group after matching. Patients who could not be adequately matched between the CT-FFR ≤ 0.8 and CT-FFR > 0.8 groups were excluded from the analysis.In terms of demographics and pre-hospital medication, the rate of receiving aspirin, beta-blockers, statins, and hypoglycemic drugs were all significantly higher in the group with CT-FFR ≤ 0.8 compared to the group with CT-FFR > 0.8. The level of uric acid, high-sensitivity C-reactive protein (hs-CRP), low-density lipoprotein (LDL), and UHR was significantly higher, while high-density lipoprotein (HDL) was lower in the group with CT-FFR ≤ 0.8. UHR was independently related with CT-FFR ≤ 0.8. For predicting the functional myocardial ischemia, UHR value was found with a sensitivity of 85.0% and a specificity of 75.0%.UHR level was significantly elevated in patients with hemodynamically significant coronary lesions. UHR may serve as a novel biomarker, absent in SMuRFs, for evaluating functional myocardial ischemia.
Keywords: uric acid to high-density lipoprotein cholesterol ratio, standard modifiable cardiovascular risk factors, functional myocardial ischemia, computed tomographyfractional flow reserve, biomarker
Received: 17 Dec 2024; Accepted: 16 Jun 2025.
Copyright: © 2025 Chen, Zhao, Gao, Zhang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ruoxi Zhang, Yinghua Hospital, Harbin, China
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