ORIGINAL RESEARCH article
Front. Med.
Sec. Nephrology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1548218
This article is part of the Research TopicTranslational Potential of Novel Biomarkers and Molecular Targets in Lifestyle DisordersView all 5 articles
The effect of VEGF, ET-1 and TGF-β 1 levels in peritoneal dialysis effluent on peritoneal solute transport function
Provisionally accepted
- 1The 945th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Ya‘an, China
- 2Ya'an Traditional Chinese Medicine Hospital, Ya'an, China
- 3Yucheng District People's Hospital of Ya'an, Ya'an, China
- 4Ya'an People’s Hospital, Yaan, Sichuan Province, China
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Objective This study aims to assess the impact of Vascular endothelial growth factor(VEGF), Endothelin-1(ET-1), and Transforming growth factor-β1(TGF-β1) levels in peritoneal dialysis effluent on peritoneal solute transport function. Methods We included 450 patients from four hospitals, spanning from January 2016 to January 2018. Patients were categorized into low-transport (D/Pcr ≤0.65) and high-transport groups (D/Pcr > 0.65) based on solute transport rates. We compared the effluent levels of VEGF, ET-1, and TGF-β 1 between the groups, employed Pearson's correlation for analysis, and used multivariate logistic regression to identify independent factors influencing solute transport. Results VEGF and TGF-β1 levels were significantly higher in the high-transport group (P<0.05), showing a positive correlation with solute transport function (r=0.721 and 0.539 respectively, P<0.05). ET-1 levels showed no significant difference between the groups. VEGF and TGF-β1 were identified as significant independent factors affecting solute transport (OR=3.438 and 3.684, P<0.05). ROC curve analysis highlighted the predictive value of VEGF and TGF-β1 for solute transport function. Kaplan-Meier and COX regression analyses indicated that high transport was associated with lower survival rates, with VEGF and TGF-β1 serving as independent risk factors for mortality (RR=3.442 and 3.550, P<0.05). Conclusion VEGF and TGF-β1 levels in peritoneal dialysis effluent are strongly correlated with solute transport function and serve as significant predictors of patient outcomes.
Keywords: Peritoneal dialysis effluent, Vascular Endothelial Growth Factor, Endothelin-1, Transforming growth factor-β1, Peritoneal solute transport function, prognosis
Received: 19 Dec 2024; Accepted: 04 Sep 2025.
Copyright: © 2025 Han, Li, Yu, Jiang, Li, Luo, Zeng and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ming Zhang, The 945th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Ya‘an, China
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