MINI REVIEW article
Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1549733
This article is part of the Research TopicFrailty- and Age-Associated Diseases: Possibilities For Intervention (Volume 2)View all 10 articles
Rsearch Progress on the Relationship between Aging and Microbiota in Sarcopenia
Provisionally accepted
- 1China Resources Wuhan Iron and Steel General Hospital, Wuhan University of Science and Technology, Wuhan, Hebei Province, China
- 2School of Medicine, Wuhan University of Science and Technology, Wuhan, China
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Sarcopenia is an age-related skeletal muscle disease associated with adverse outcomes such as falls, decreased function, frailty, and death, and is a significant global public health problem that impairs the functioning of individuals. Aging is intensifying, the number of people with sarcopenia is increasing, and there are currently no specific treatment drugs for sarcopenia.The clinical pathogenesis of sarcopenia is extremely complex, and the underlying mechanism of immunosenescence and dysbiosis associated with aging on sarcopenia is not well studied, and they are also potential therapeutic targets for sarcopenia. This review mainly discusses the relationship between sarcopenia from the perspective of intestinal microbiota dysbiosis and T cell changes in immunosenescence, and looks for promising targets for diagnosis or intervention of sarcopenia in the future, hoping to achieve early detection, early diagnosis and early treatment of sarcopenia and prolong the life span of healthy aging.
Keywords: Sarcopenia, Gut Microbiota, immunosenescence, T cell senescence, Intestinal dysbacteria
Received: 21 Dec 2024; Accepted: 21 Jul 2025.
Copyright: © 2025 Cheng, Chen and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jia-Xin Chen, China Resources Wuhan Iron and Steel General Hospital, Wuhan University of Science and Technology, Wuhan, Hebei Province, China
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