BRIEF RESEARCH REPORT article
Front. Med.
Sec. Pathology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1553910
Characterization of Intrinsic Subtypes of Breast Cancer and Their Relationship with Staging: An Observational Study
Provisionally accepted
Paola Tapia-Uriol1Lorena Becerra-Goicochea2*Victor Campos-Valderrama1Juana del Valle-Mendoza3Miguel Angel Aguilar-Luis3
Wilmer Silva-Caso3*- 1Hospital Regional Docente de Cajamarca, Cajamarca, Peru
- 2Escuela Academico Profesional de Obstetricia, Universidad Nacional de Cajamarca, Cajamarca, Peru
- 3Universidad Peruana de Ciencias Aplicadas, Lima, Peru
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Breast cancer is one of the main causes of morbidity and mortality among women around the world. Studying the relationship between intrinsic breast cancer subtypes and disease staging can optimize diagnosis, prognosis and treatment.The objective of the study was to analyze the distribution of intrinsic subtypes of breast cancer and their correlation with prognostic factors and demographic characteristics among women in Peru. A descriptive, retrospective observational study was conducted, analyzing 67 cases of breast cancer of various intrinsic subtypes diagnosed, demographic, and pathological data were collected, including histological type, intrinsic subtype, tumor stage and geographic origin of the patients. Intrinsic subtypes were classified through immunohistochemistry, and the data were processed to determine their distribution and correlation with prognostic factors such as disease stage. Of the total, most cases originated in the city of Cajamarca (56.7%, n = 38). Invasive breast carcinoma of no special type was the most common histological type (62.7%, n = 42). Among the intrinsic subtypes, luminal B was the most common (31.3%, n = 21), followed by luminal A and triple negative (22.4%, n = 15), both with the same frequency. Furthermore, 16.4% (n = 11) were observed to have metastasis at the time of evaluation, and a high frequency of tumors in TNM stages 3 and 4 (49.2%, n = 33).This study describes the heterogeneity of breast cancer based on the identification of intrinsic subtypes within the analyzed population. The high frequency of Luminal B, Luminal A, and triple-negative subtypes is notable.
Keywords: Carcinoma, ductal, Breast, Breast neoplasm, breast carcinomas
Received: 31 Dec 2024; Accepted: 16 Apr 2025.
Copyright: © 2025 Tapia-Uriol, Becerra-Goicochea, Campos-Valderrama, del Valle-Mendoza, Aguilar-Luis and Silva-Caso. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lorena Becerra-Goicochea, Escuela Academico Profesional de Obstetricia, Universidad Nacional de Cajamarca, Cajamarca, Peru
Wilmer Silva-Caso, Universidad Peruana de Ciencias Aplicadas, Lima, Peru
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