CASE REPORT article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1555471
Polyinfection secondary to exogenous lipoid pneumonia caused by aspiration of paraffin oil: a case report
Provisionally accepted
- Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
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Background:ELP is a rare condition caused by the aspiration of lipid-containing substances. Its diagnosis can be challenging due to nonspecific respiratory symptoms and imaging findings. Complications, such as secondary infections, may exacerbate the clinical course, particularly in immunocompromised or elderly patients. No cases of ELP complicated by concurrent viral (SARS-CoV-2), bacterial, and fungal infections have been reported in recent literature.Case Presentation:We present the case of a 90-year-old female who developed ELP following the use of oral paraffin oil for ileus management. Initial symptoms included fever, cough, and respiratory distress, with rapidly worsening dyspnea. A chest CT revealed fat-density consolidations. Lipid droplets and lipid-laden macrophages were found in the bronchoalveolar lavage fluid. Her condition was further complicated by polymicrobial infections, including SARS-CoV-2, Mycobacterium abscessus, Klebsiella pneumoniae, and Candida albicans. A comprehensive treatment approach combining antibiotics, antifungals, antivirals, and corticosteroids resulted in significant clinical and radiological improvement over one week.Conclusion:This case underscores the importance of early recognition of ELP, particularly in high-risk populations, and highlights the need for a multidisciplinary approach to manage secondary infections. Systemic corticosteroids and tailored antimicrobial therapy proved effective in this critically ill patient.
Keywords: Exogenous lipoid pneumonia, paraffin oil aspiration, Polymicrobial infections, Corticosteroid therapy, Bronchoalveolar Lavage, SARS-CoV-2
Received: 04 Jan 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Yan, Chen, Zhu, Chen, Meng, Li, Tang, Zhang, Yi and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yan Fu, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
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