ORIGINAL RESEARCH article
Front. Med.
Sec. Nephrology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1556584
This article is part of the Research TopicInfluence of Social Determinants on Wellbeing in Chronic Kidney Disease PatientsView all 10 articles
Type of the study: Original Research Article The Role of Serum Biomarkers in the decline of Cognitive Function in Hemodialysis Patients：a single-center retrospective study
Provisionally accepted
- 1First People's Hospital of Changzhou, Changzhou, China
- 2Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China
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Background. Cognitive impairment in hemodialysis patients is higher than that in healthy individuals. However, the potential pathogenesis is not fully clear.In this retrospective study, 48 maintenance hemodialysis (MHD) patients of our centre who participated in cognitive level test four years ago were screened by Montreal Cognitive Assessment (MoCA). We then analysed relationships between the MoCA-derived cognitive level score, demographic, clinical and laboratory variables.Results. The age, dialysis age, Body Mass Index (BMI), and blood calcium levels of MHD patients were significantly abnormal than 4 years ago in this study. Furthermore, we observed that the levels of Fibroblast growth factor (FGF-23) in MHD patients with cognitive decline were significantly higher than those in the normal cognitive group. Receiver operating characteristic (ROC) curves demonstrated that FGF-23 was a potential biomarker for diagnosing cognitive decline in hemodialysis patients.Conclusions. We speculate that dialysis age, increased BMI, decreased blood calcium, and the abnormal level of FGF-23 may be independent risk factors for cognitive impairment in hemodialysis patients. Moreover, BMI and decreased blood calcium can be used as predictive factors of hemodialysis-related cognitive impairment.
Keywords: hemodialysis, cognitive decline, Serum biomarkers, Risk factors, Quality of Life
Received: 07 Jan 2025; Accepted: 12 Aug 2025.
Copyright: © 2025 li, Jiang, zhu, yu, Miao and shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Liying Miao, First People's Hospital of Changzhou, Changzhou, China
jianqin shen, First People's Hospital of Changzhou, Changzhou, China
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