ORIGINAL RESEARCH article
Front. Med.
Sec. Dermatology
Rapid cutaneous wound healing in nude mice by fetal skin-derived stem cells involves enhanced collagen secretion and angiogenesis
Provisionally accepted
- Jilin University, Changchun, China
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Stem cells are used to treat chronic non-healing wounds. However, the seed cells required for optimal healing remain unknown. In this study, we evaluate the effects of fetal skin-derived stem cells (FSSCs) on a nude mice cutaneous wound model and compare them with adipose-derived mesenchymal stem cells (ADSCs). Both stem cell types exhibit polygonal or spindlelike morphology and differentiate into adipocytes, osteoblasts, and chondrocytes. FSSCs express CD90, CD44, CD73, and CD105, but not CD34, CD45, or CD14. Additionally, they display a lower expression of HLA-DR compared to ADSCs. In vitro, FSSCs have stronger proliferation, migration, and collagen secretion than ADSCs and promote tube formation in human umbilical vein endothelial cells, which is crucial for wound healing. In vivo, FSSCs accelerate cutaneous wound healing in nude mice compared to ADSCs. Furthermore, after intervention with FSSCs, the expression of collagen and angiogenesis-related proteins (CD31 and vascular endothelial growth factor) in the skin tissue significantly increased, and the secretion of inflammatory mediators (TNF-α, IL-6, IL-10, and IL-13) was regulated. Hence, FSSCs are more promising in accelerating wound healing and are closely related to their ability to promote fibroblast proliferation, angiogenesis, and collagen secretion, providing a novel treatment strategy for accelerating wound healing.
Keywords: fetal skin-derived stem cells, Adipose-derived mesenchymal stem cells, FibroblastProliferation, Chronic non-healing wounds, Wound Healing
Received: 09 Jan 2025; Accepted: 03 Nov 2025.
Copyright: © 2025 Geng, Zhang, Dun, Wang and Shao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ying Shao, shao_ying@jlu.edu.cn
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