CASE REPORT article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1561843
Acute lymphoblastic leukemia with Fusarium solani infection: A case report
Provisionally accepted
- 1Hangzhou Red Cross Hospital, Hangzhou, Zhejiang Province, China
- 2Department of Infection, Hangzhou Xixi hospital, Hangzhou, China
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BackgroundFusarium infections are rare but life-threatening in immunocompromised patients, particularly those with acute lymphoblastic leukemia (ALL) undergoing chemotherapy. This case report describes a patient with ALL who developed multifocal cutaneous Fusarium solani infections following VDCLP chemotherapy, highlighting the challenges in diagnosis and management.Case PresentationA 27-year-old male ALL patient developed cutaneous infections on the right calf, left upper arm, and buttock during chemotherapy. Initial lesions presented as a 1.0×1.0 cm dark purple nodule on the right calf, progressing rapidly to black eschar, ulceration, and multiple metastatic lesions. Fusarium solani was confirmed via microbiological culture and molecular testing. Treatment included systemic voriconazole, local debridement, topical liposomal amphotericin B, G-CSF for neutrophil recovery, and psychological intervention for anxiety. The infections were effectively controlled with gradual wound healing, and no recurrence was observed during two months of follow-up.ConclusionUnusual skin lesions in immunocompromised patients, especially those with hematological malignancies receiving chemotherapy, warrant high suspicion for Fusarium infection. Timely microbiological diagnosis and early initiation of combined systemic-topical antifungal therapy, alongside neutrophil support and multidisciplinary care, are critical for improving outcomes.
Keywords: Model construction, statistics, Language correction, methodology, Software, supervision, Validation, visualization
Received: 17 Jan 2025; Accepted: 29 May 2025.
Copyright: © 2025 Liang, Ni, Ni, Zhang and Ai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xu Zhang, Hangzhou Red Cross Hospital, Hangzhou, 310004, Zhejiang Province, China
Qinqin Ai, Department of Infection, Hangzhou Xixi hospital, Hangzhou, China
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