ORIGINAL RESEARCH article
Front. Med.
Sec. Nuclear Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1565525
Prognostic value of a simple distance index derived from PET maximum intensity projection
Provisionally accepted
Isaac Kargar Samani1,2*
Olivier Gheysens1
Maxime Regnier3Alix Collard4Marc André2Eric Van Den Neste1Thierry Vander Borght2- 1Cliniques Universitaires Saint-Luc, Woluwe-Saint-Lambert, Brussels, Belgium
- 2CHU UCL Namur Site Godinne, Namur, Belgium
- 3University of Namur, Namur, Belgium
- 4Université Catholique de Louvain, Louvain-la-Neuve, Walloon Brabant, Belgium
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Dissemination indices derived from [ 18 F]FDG PET/CT, such as Dmax, Dmax bulk , SPREAD bulk , SPREAD patient , and Dmax Vox are validated prognostic biomarkers in diffuse large B-cell lymphoma. We introduce Dmax VoxMIP , the distance between the outermost voxels of the two most distant lesions on a 2D maximum intensity projection image, which is easy and straightforward to obtain. Our goal is to evaluate Dmax VoxMIP 's prognostic value compared to other features for easier clinical application. Metabolic tumor volume and dissemination indices were obtained from LIFEx, while Dmax VoxMIP was obtained from Telemis and OsiriX. Dmax VoxMIP was not significantly higher in deceased than in living patients. However, patients with Dmax VoxMIP values above the derived cutoff showed a shorter survival. By combining MTV and Dmax VoxMIP , we obtained 3 risk groups for OS and PFS. Dmax VoxMIP could advantageously replace other dissemination parameters as a prognostic index in patients with DLBCL.
Keywords: [ 18 F]FDG PET/CT, oncology, Lymphoma, DLBCL, dissemination
Received: 23 Jan 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Kargar Samani, Gheysens, Regnier, Collard, André, Van Den Neste and Vander Borght. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Isaac Kargar Samani, Cliniques Universitaires Saint-Luc, Woluwe-Saint-Lambert, 1200, Brussels, Belgium
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.