CASE REPORT article
Front. Med.
Sec. Dermatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1565977
Case report: Epidermodysplasia verruciformis with multiple squamous and basal cell carcinomas
Provisionally accepted
- 1Zhejiang Chinese Medical University, Hangzhou, China
- 2Hangzhou First People's Hospital, Hangzhou, Zhejiang Province, China
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Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by chronic infection with human papillomavirus (HPV), leading to disseminated flat-topped papules and pityriasis versicolor-like lesions. Patients with EV are predisposed to developing non-melanoma skin cancers, particularly squamous cell carcinoma (SCC) in sun-exposed areas. Currently, there is no definitive cure for EV, and management remains largely supportive and symptomatic. We report a case of EV in a 38-year-old male, presenting with classical clinical features and histopathological findings, complicated by the simultaneous development of squamous cell carcinoma(SCC) and basal cell carcinoma (BCC). This case highlights the oncogenic potential of EV-associated HPV subtypes and the importance of regular dermatologic surveillance in affected individuals.
Keywords: Epidermodysplasia Verruciformis, Squamous cell carcinoma, basal cell carcinoma, Histopathological examination, malignancy
Received: 24 Jan 2025; Accepted: 12 May 2025.
Copyright: © 2025 Zhang, Liu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jinsheng Li, Hangzhou First People's Hospital, Hangzhou, 310006, Zhejiang Province, China
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