ORIGINAL RESEARCH article
Front. Med.
Sec. Hepatobiliary Diseases
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1565997
This article is part of the Research TopicHot Topics in Diabetes and Steatotic Liver DiseaseView all 12 articles
Lipid Accumulation product and NAFLD in Normal Weight
Provisionally accepted
- 1Shenzhen Traditional Chinese Medicine Hospital, Shenzhen ，Guangdong, China
- 2Shenzhen Second People's Hospital, Shenzhen, China
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Background:Previous studies have indicated that Lipid accumulation product (LAP) can serve as a predictor for various metabolic diseases. However, the relationship between LAP and Non-alcoholic fatty liver disease (NAFLD) in individuals with normal weight remains unclear.This study involves a secondary analysis of a retrospective cohort study conducted among a Japanese population consisting of 10,391 participants with normal weight, spanning from 2004 to 2015. LAP is determined by utilizing Waist circumference (WC) and Triglyceride (TG) levels. Participants were categorized into groups based on LAP quartiles.We performed an analysis of the association between LAP and NAFLD using Cox proportional-hazard regression, smooth curve fitting, and sensitivity analyses.Prediction accuracy was evaluated using the area under the curve (AUC) analysis, sensitivity, and specificity, using Receiver Operating Characteristic (ROC) curves.The analysis revealed a statistically significant positive correlation between LAP and normal-weight NAFLD (P < 0.01). Following adjustment for various covariates in the full models, LAP was found to be associated with NAFLD (OR = 1.06, 95%CI: 1.04-1.08, P < 0.001). Sensitivity analysis was conducted by categorizing LAP as a quartile variable, showing that the top quartile had a 354% increased risk of NAFLD compared to the bottom quartile in the full model Lipid Accumulation product and NAFLD in Normal Weight 2 (OR = 4.54, 95%CI: 2.83-7.3, P < 0.001).A non-linear relationship was observed between the LAP and normal-weight NAFLD, with an inflection point identified at a LAP value of 12.6.Furthermore, ROC curve analysis demonstrated that LAP (AUC = 0.809, sensitivity = 83.3%, specificity = 64.7%) had superior predictive accuracy for normal-weight NAFLD compared to Body mass index (BMI ) and WC.: Our study reveals a nonlinear association between the LAP and the risk of NAFLD in individuals of normal weight, with LAP demonstrating superior predictive accuracy compared to BMI and WC. These results advocate for the use of LAP thresholds to guide early lifestyle interventions during metabolically reversible stages and to improve the identification of high-risk lean individuals who may be overlooked by current BMI-based screening methods.
Keywords: Lipid accumulation product, Non-alcoholic fatty liver disease, Normal weight, LAP, NAFLD
Received: 24 Jan 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Shen, Lin, Chen and Peng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hui Peng, Shenzhen Second People's Hospital, Shenzhen, China
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