ORIGINAL RESEARCH article
Front. Med.
Sec. Rheumatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1567303
Global, Region and Country Burden of Osteoarthritis at Different Sites in Middle-Aged and Elderly Populations from 1990 to 2021: A Systematic Analysis of the 2021 Global Burden of Disease Study
Provisionally accepted
Guoxin Huang1
Yiwen Zheng2Weimin Hong3Xiaohong Qu4Wentao Yang1Hui Cao1Fangtao Tian1Hongming Lin1
Bin Pei1Bingqian Chen4*shu‘e Yang5*
Da Qian4*- 1The First People's Hospital of Xiangyang City, Xiangyang, Hebei Province, China
- 2Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Province, China
- 3Shenzhen Luohu People's Hospital, Shenzhen, China
- 4Changshu No.1 People's Hospital, Suzhou, China
- 5Xiangyang City Hospital for Tuberculosis, Xiangyang, China
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Objective: To explore the burden and trend of osteoarthritis (OA) at different sites in middle-aged and elderly people (45 years and older) from 1990 to 2021.Age-standardized incidence rates, prevalence rates, disability-adjusted life years (Daly) rates and average annual percent change were used to quantify the disease burden and trend of OA at different sites. Decomposition analysis was conducted to explore the impact of three population-level determinants on the burden of OA and the distribution of OA burden inequality in the Socio-Demographic Index (SDI) across countries.The age-standardized prevalence rate had increased by 8.9%, and the OA cases had increased by 2.41 times compared to 1990.The incidence and prevalence of knee, hip and hand OA decreased sequentially, while high SDI regions tended to have higher age-standardized incidence rates, prevalence rates and Daly rates. Decomposition analysis revealed that 85.9% of the increase in OA age-standardized Daly rates was attributable to population growth. This increase was most pronounced in high SDI populations for hip OA and middle SDI populations for knee and hand OA. From 1990 to 2021, the inequality in overall OA burden between countries had decreased. The absolute inequality gap for hand OA had narrowed the most significantly (45.3%), which followed by knee OA (11.9%), while the inequality gap for hip OA has slightly increased.In summary, all parts of the OA burden in middle-aged and elderly people hads steadily increased from 1990 to 2021, which calls to implement personalized prevention targeting different parts of OA.
Keywords: Osteoarthritis, disease burden, Decomposition analysis, Health Inequalities Analysis, Middle-aged and elderly people
Received: 27 Jan 2025; Accepted: 28 Apr 2025.
Copyright: © 2025 Huang, Zheng, Hong, Qu, Yang, Cao, Tian, Lin, Pei, Chen, Yang and Qian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bingqian Chen, Changshu No.1 People's Hospital, Suzhou, China
shu‘e Yang, Xiangyang City Hospital for Tuberculosis, Xiangyang, China
Da Qian, Changshu No.1 People's Hospital, Suzhou, China
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