REVIEW article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1568333
This article is part of the Research TopicEndothelium, Innate Immunity and Coagulation in Hematological DisordersView all 7 articles
Anticoagulant regimens for different therapeutic plasma exchange modes
Provisionally accepted
Ruishan Yao
黄 海燕Yaohui MingHuiling GuoLingli Miao
Su Wang
Jia WanJin ZhouXiaofang WangYanli WuYaowen YuanTing Wang
Ruiting Li*- Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Therapeutic plasma exchange (TPE) is widely used in various fields of clinical practice. There are two main modes of TPE: centrifugal TPE (cTPE) and membrane TPE (mTPE). No matter which mode of TPE, anticoagulant therapy is essential to prevent clotting in the extracorporeal circuit. Therefore, selecting a suitable and safe anticoagulant is crucial. Currently, heparin and citrate are the most commonly used anticoagulants. Different anticoagulant regimens have varying advantages, disadvantages, and associated complications, making them suitable for different TPE modes. This review aims to summarize relevant research findings to provide clinicians with evidence to guide their selection of appropriate anticoagulants during TPE.
Keywords: therapeutic plasma exchange, centrifugal tPE, membrane tPE, Anticoagulant therapy, Anticoagulant drug
Received: 29 Jan 2025; Accepted: 28 May 2025.
Copyright: © 2025 Yao, 海燕, Ming, Guo, Miao, Wang, Wan, Zhou, Wang, Wu, Yuan, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ruiting Li, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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