ORIGINAL RESEARCH article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1576953
Biometric Parameters and Choroidal Microstructure in Chinese Children with Unilateral Anisometropia
Provisionally accepted
- First Hospital, Peking University, Beijing, China
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Purpose: The present study aimed to investigate the biological parameters and choroidal microstructure of the eyes of children with unilateral anisometropia and to analyze the factors influencing refractive development in these patients. Methods: This observational cross-sectional study included 26 patients with unilateral hyperopic anisometropia and 34 patients with unilateral myopic anisometropia. Biometric parameters, including axial length (AL) and average keratometry (Ave-K), were measured. Choroidal thickness (CT) and vascular microstructure parameters, including the total choroidal area (TCA), luminal area (LA), stromal area (SA), and choroidal vascularity index (CVI), were obtained with enhanced depth imaging optical coherence tomography (EDI-OCT). Results: Compared with those in normal eyes, the AL and AL/K ratio were significantly lower in hyperopic eyes but significantly greater in myopic eyes (all P <0.001). The TCA and LA were significantly greater in hyperopic eyes and significantly lower in myopic eyes than in normal eyes (all P<0.005). The LA/SA ratio and CVI were significantly lower in myopic eyes (P=0.002, P<0.001) and nonsignificantly greater in hyperopic eyes than in normal eyes (P=0.072, P=0.050). In hyperopic anisometropia, interocular differences in both the AL and AL/K ratio were negatively correlated with subfoveal choroidal thickness (AL: r = −0.529, P = 0.005; AL/K: r = −0.612, P = 0.001) and the LA (AL: r = −0.393, P = 0.047; AL/K: r = −0.407, P = 0.039). Conclusions: Significant negative correlations between axial length and choroidal parameters (SFCT/LA) in hyperopic anisometropia suggest that axial elongation may be associated with choroidal thinning. The CVI decreases as hyperopia progresses to emmetropia and then to myopia, indicating that choroidal vascularity changes during refractive development.
Keywords: unilateral anisometropia, Axial length, Choroidal thickness, choroidal vascularity index, EDI-OCT
Received: 04 Mar 2025; Accepted: 15 Jul 2025.
Copyright: © 2025 Wen, Cao, Zhao and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dehai Zhu, First Hospital, Peking University, Beijing, China
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