SYSTEMATIC REVIEW article
Front. Med.
Sec. Precision Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1577396
Global trends in Recombinant Human Growth Hormone for the Treatment of Idiopathic Short Stature: A Bibliometric Analysis
Provisionally accepted
- Affiliated Hospital of Nantong University, Nantong, China
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Background: The treatment of idiopathic short stature (ISS) with recombinant human growth hormone (rhGH) has been a subject of extensive research. This study aims to perform a bibliometric analysis of publications related to rhGH treatment for ISS, identifying research hotspots, key publications, and international collaboration networks. Method: A literature search was conducted on the Web of Science Core Collection, covering literature from 1991 to 2024. Bibliometric tools including CiteSpace, VOSviewer and “bibliometrix” package of R were used to analyze publication trends, authorship, institutional contributions, and citation networks. Keyword co-occurrence and burst detection were performed to identify emerging research topics. Results: This area of study had experienced significant growth and maturation over the past three decades, characterized by increasing interest and investment in research pertaining to rhGH interventions for ISS. The majority of research output was concentrated in China. Leading contributors to this body of work included the University of Ulsan. The most prolific academic journals in this field were the Journal of Clinical Endocrinology & Metabolism. The keyword co-occurrence analysis identified “gene,” “mutations,” and “genotype,” highlighting genetic factors in rhGH therapy for ISS. Keyword burst analysis, however, emphasized recent trends like “safety” and “growth hormone deficiency,” reflecting growing attention to treatment risks and patient-specific care. Conclusion: This bibliometric analysis highlights the progression of rhGH research for ISS, shifting from foundational studies to contemporary priorities such as tailored therapies and clinical outcomes. Future research should focus on advancing precision medicine and optimizing treatment protocols while addressing safety concerns and long-term effectiveness.
Keywords: Recombinant human growth hormone, idiopathic short stature, Bibliometric, BIB, Global trends
Received: 15 Feb 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Ouyang, Gu, Yuan, Zhao and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Rong Ouyang, Affiliated Hospital of Nantong University, Nantong, China
Haiyun Gu, Affiliated Hospital of Nantong University, Nantong, China
Jie Yuan, Affiliated Hospital of Nantong University, Nantong, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.