ORIGINAL RESEARCH article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1580023
This article is part of the Research TopicMyopia in Childhood and AdolescenceView all 11 articles
Factors Affecting Myopia Control Outcomes with Orthokeratology Treatment in Children: A Retrospective Analysis
Provisionally accepted
- 1School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang Province, China
- 2Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China
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Purpose: This retrospective observational cohort study aimed to analyze the factors influencing the effectiveness of orthokeratology (OrthoK) lens treatment in controlling myopia in children. Methods: Medical records of 200 children aged 8-15 years, with spherical equivalent refraction (SE) ranging from -1.00 to -6.00 diopters (D) and binocular anisometropia less than 1.00D, were analyzed. The data included baseline age, SE, keratometry readings (Kf and Ks), corneal eccentricity, asymmetry indices, pupil size, and corneal diameter. Multivariate linear regression analysis was used to identify factors associated with axial length (AL) changes over a one-year period. Additional analyses explored the relationship between treatment outcomes and lens centration parameters.The mean axial length (AL) growth after one year was 0.20±0.16mm.Multivariate analysis identified baseline age (β=-0.725, p<0.001) and baseline SE (β=1.289, p<0.001) as significant predictors of AL change. Subgroup analyses showed that children older than 11 years with baseline SE greater than -3.00D exhibited the most favorable treatment outcomes. Lens decentration patterns were significantly correlated with treatment efficacy (p<0.05).OrthoK treatment outcomes are significantly influenced by baseline age and refractive error. The findings suggest that patient age and the severity of initial myopia should be considered when predicting treatment outcomes. Further prospective studies are required to validate these findings and investigate the role of lens centration in treatment efficacy.
Keywords: Orthokeratology, Myopia control, Axial length, Refractive error, Pediatric optometry, Lens decentration, Corneal Topography
Received: 20 Feb 2025; Accepted: 09 May 2025.
Copyright: © 2025 Wang, Wang, Yin, Yang, Zhan, Deng and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jun Deng, Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, Zhejiang Province, China
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