ORIGINAL RESEARCH article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1581608
This article is part of the Research TopicProgress and Perspectives in Surgical Management of GlaucomaView all articles
Comparative effectiveness and safety of GATT with or without ABiC in patients with open-angle glaucoma
Provisionally accepted
Weijia Zhang1
Yiwei Wang2
Chen Xin3,4
Ke Zhang1Zhen Yang1Jinghong Sang3,4
Chun Zhang1,5,6*
Huaizhou Wang3,4*- 1Department of Ophthalmology, Peking University Third Hospital, Beijing, China
- 2Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, Henan Province, China
- 3Beijing Tongren Hospital, Capital Medical University, Beijing, China
- 4Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China
- 5Eye Center, Beijing Tsinghua Changgung Hospital, Beijing, Beijing, China
- 6Beijing Visual Science and Translational Eye Research Institute, Beijing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: This is the first comprehensive comparison between gonioscopy-assisted transluminal trabeculotomy (GATT) and GATT combined with ab interno canaloplasty (ABiC) in patients with OAG.The purpose of this study was to compare the efficacy and safety of gonioscopy-assisted transluminal trabeculotomy (GATT) combined with ab interno canaloplasty (ABiC) with those of GATT alone in patients with open-angle glaucoma (OAG).Design: This was a retrospective, comparative case series.Patients with primary open angle glaucoma who underwent GATT (27 eyes in Group 1) or GATT + ABiC (26 eyes in Group 2) were included.Methods: Outcomes including intraocular pressure (IOP), glaucoma medications, and surgical complications were analyzed.Main Outcome Measures: Surgical success was defined in terms of IOP and medication use as follows: 1) a preoperative IOP > 21 mmHg and a postoperative IOP ≤ 21 mmHg with at least a 20% reduction from baseline with (qualified success) or without (complete success) glaucoma medications or 2) a preoperative IOP < 21 mmHg while taking 3 or more glaucoma medications and a postoperative IOP ≤ 21 mmHg with a reduction of more than two medications (qualified success) or with no medications (complete success).Results: At 12 months, the mean IOP was 14.8±2.2 mmHg in Group 1 and 16.6±2.3 mmHg in Group 2 (P=0.008). The number of medications was 0.6±1.0 in Group 1 and 0.9 ± 1.3 in Group 2 (P=0.334). At 24 months, the mean IOP was 15.3±2.0 mmHg in Group 1 and 15.5±2.4 mmHg in Group 2 (P=0.676). The number of medications was 0.5±0.9 in Group 1 and 0.9±1.1 in Group 2 (P=0.197). The complete success rates were 63.0% in Group 1 and 50.0% in Group 2 (P=0.16), and the qualified success rates were 81.5% in Group 1 and 76.9% in Group 2 (P=0.51).The GATT procedure, with or without ABiC, is safe and effective in decreasing the IOP and the number of antiglaucoma medications used.
Keywords: Gonioscopy-assisted transluminal trabeculotomy, Ab interno canaloplasty, minimally invasive glaucoma surgery, Open-angle glaucoma main text, Intraocular Pressure
Received: 24 Feb 2025; Accepted: 06 Aug 2025.
Copyright: © 2025 Zhang, Wang, Xin, Zhang, Yang, Sang, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chun Zhang, Department of Ophthalmology, Peking University Third Hospital, Beijing, China
Huaizhou Wang, Beijing Tongren Hospital, Capital Medical University, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.