BRIEF RESEARCH REPORT article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1582422
This article is part of the Research TopicIntraocular Pressure Evaluation and Confounding ParametersView all 4 articles
The Relationship Between the Intraocular Position of Dexamethasone Intravitreal Implant and Post-Injection Intraocular Pressure Elevation
Provisionally accepted
- Dalian No.3 People's Hospital, Dalian, China
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Objective: To investigate the relationship between the implantation position of dexamethasone intravitreal implant (DEX-I) and post-injection intraocular pressure (IOP) elevation. Methods: This retrospective study included 324 patients (332 eyes) who received at least one DEX-I injection between June 2020 and June 2024, with a follow-up period of at least three months. Patient demographics, diagnoses, and DEX-I implantation positions were recorded. The correlation between implantation position and post -injection IOP elevation was analyzed. IOP elevation was defined as an IOP greater than 25 mmHg and/or an increase of 10 mmHg from baseline. DEX-I implantation positions were defined as follows: P1: implant located in the vitreous near the ciliary body, anterior to the ora serrata (with or without ciliary body contact); P2: implant located in the vitreous from the ora serrata to the pre-equatorial region; P3: implant located in the post-equatorial vitreous. The equator was defined by the vortex veins.Results: During the follow-up period, 68 eyes (20.48%) experienced IOP elevation. Compared to P2 and P3, the P1 implantation position was significantly associated with a higher incidence of IOP elevation (P < 0.001) and was positively correlated with early IOP elevation (within 15 days post-injection) (r = 0.761; P < 0.001).Conclusion: The P1 implantation is positively correlated with IOP elevation, particularly with early IOP elevation.
Keywords: Dexamethasone intravitreal implant, implantation position, Intraocular pressure elevation, DEX-i, IOP
Received: 24 Feb 2025; Accepted: 28 Aug 2025.
Copyright: © 2025 Liu, Chen, Fu, Zhao, Ji, Qiu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sheng Li, Dalian No.3 People's Hospital, Dalian, China
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