STUDY PROTOCOL article
Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1582533
This article is part of the Research TopicCellular Senescence in Aging-Related Diseases: Mechanisms and Therapeutic TargetsView all 5 articles
Prevalence, Clinical Characteristics, and Biological Markers of Postmenopausal Osteoporosis and Knee Osteoarthritis in Beijing: Study Protocol for a Cross-Sectional and Prospective Study
Provisionally accepted
Zhenkai Lu1
Wenye Feng1
Yaxing Wang1Xuming Zhang1
Xu Wei2Ming Chen2Shangquan Wang2Ting Cheng2
Xin Cui1*
Yanming Xie1*- 1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
- 2Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China
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Background: Postmenopausal osteoporosis (PMOP) and knee osteoarthritis (KOA) are common musculoskeletal disorders that share risk factors such as aging, hormonal changes, and inflammation. PMOP often remains asymptomatic until fractures occur, while KOA leads to pain and disability. Their comorbidity remains underexplored, particularly in community settings. This study aims to investigate the prevalence, risk factors, and clinical features of PMOP-KOA comorbidity among Beijing residents aged 45-80 years, providing evidence-based recommendations for early identification, prevention, and management. Methods: Over 2 years, this study will conduct a PMOP-KOA screening and prospective follow-up in the Beijing community to investigate the incidence, risk factors, and clinical characteristics of PMOP-KOA. This study will undertake bone mineral density detection, collect biological samples, and record information via questionnaires. Discussion: The study aims to investigate the incidence, risk factors, and clinical characteristics of PMOP-KOA comorbidity and explore related traditional Chinese medicine syndromes based on large community-based samples in Beijing. Data on PMOP-KOA occurrence and associated risk factors over the two-year follow-up will be available on the Chinese Clinical Trial Registry (ChiCTR2300073575).
Keywords: Postmenopausal osteoporosis, knee osteoarthritis, Cross-sectional study, Prospective, follow-up, Risk factors 1
Received: 24 Feb 2025; Accepted: 14 May 2025.
Copyright: © 2025 Lu, Feng, Wang, Zhang, Wei, Chen, Wang, Cheng, Cui and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xin Cui, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
Yanming Xie, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
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