ORIGINAL RESEARCH article
Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1582683
Oxaliplatin combined with capecitabine therapy and comprehensive nursing in advanced colorectal cancer patients
Provisionally accepted
- 1Department of Nursing, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu 214122, China., Wuxi, China
- 2Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu 214122, China., Wuxi, China
- 3Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangnan University, Wuxi, China., Wuxi, China
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Objective: To discuss the influence of oxaliplatin plus capecitabine therapy and comprehensive nursing in advanced colorectal cancer (CRC) patients. Methods: One hundred advanced CRC patients chosen from our hospital from January 2019 to January 2021 were divided into a control group (CG) and a research group (RG). Patients in the CG adopted capecitabine tablets and routine nursing. Patients in the RG received capecitabine tablets + intravenous infusion of oxaliplatin and comprehensive nursing. The short-term effects, levels of tumor markers, immune function, quality of life, occurrence of adverse reactions, negative emotions, as well as long-term survival rate in both groups were compared. Results: Relative to the CG, the RG had higher total effective rate (P<0.05), lower CA125 and CA199 levels (P<0.05), higher CD4 + and CD4 + /CD8 + levels (P<0.05), higher KPS score, lower occurrence of adverse reactions (P<0.05), lower SAS and SDS scores (P<0.05), and better longterm survival rate of patients after 2 years of follow-up (P<0.05).Oxaliplatin plus capecitabine therapy combined with comprehensive nursing can effectively reduce clinical symptoms, improve immune capacity, together with promote the quality of life of advanced CRC patients.
Keywords: colorectal cancer, oxaliplatin, capecitabine, chemotherapy, Comprehensive nursing
Received: 24 Feb 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Kuang, Xu and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoming Shen, Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangnan University, Wuxi, China., Wuxi, China
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