CASE REPORT article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1583891
Neurobrucellosis with Negative Serological Examination: A case report and literature review
Provisionally accepted
- Lanzhou University Second Hospital, Lanzhou, China
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Neurobrucellosis is an uncommon occurrence that can arise as a consequence of brucellosis. However, its clinical symptoms are severe and have the potential to be lifethreatening. Timely detection, prompt diagnosis, and early treatment are crucial factors.Clinically, the gold standard for diagnosing pathogenic microorganisms is through culture. However, this method is hindered by its lengthy culture duration, low rate of positive results, and the absence of typical clinical signs of neurobrucellosis.Consequently, misdiagnosis and delayed treatment are common. Metagenomics nextgeneration sequencing (mNGS) technology is a novel approach in microbiological diagnosis that enables the simultaneous detection of all microorganisms present in a sample, including viruses, bacteria, fungus, and parasites. This method holds significant diagnostic significance for viral disorders affecting the central nervous system. This paper reports a case of neurobrucellosis detected by mNGS after a negative serological test, as well as a review of the relevant literature.
Keywords: Keyword Neurobrucellosis, metagenomic next-generation sequencing, diagnosis, Treatment, Brucella
Received: 26 Feb 2025; Accepted: 16 May 2025.
Copyright: © 2025 Yuan, Jiang, Han and Wang Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Manxia Wang Wang, Lanzhou University Second Hospital, Lanzhou, China
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