ORIGINAL RESEARCH article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1584473
This article is part of the Research TopicNew Concepts, Advances, and Future Trends in Clinical Research on Eye DiseasesView all 41 articles
Association between Tear Lactoferrin, Lysozyme, Albumin Levels and Obstructive Sleep Apnea Syndrome: A Cross-sectional Study
Provisionally accepted
- 1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China
- 2Department of Ophthalmology, Tongde Hospital of Zhejiang Province, Hangzhou, China
- 3Department of Ophthalmology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Province, China
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Background: Obstructive Sleep Apnea Syndrome (OSAS) is associated with various ocular diseases, but its relationship with tear biomarkers for dry eye remains unclear. This study aimed to investigate these tear biomarkers and their correlation with OSAS.Methods: This cross-sectional study was conducted at a tertiary hospital in Zhejiang Province from January 2021 to December 2022. Forty-one OSAS patients were enrolled. Tear lactoferrin, lysozyme, and albumin levels (exposure variables) were measured using ELISA, while OSAS (outcome variable) was diagnosed through polysomnography. Age, gender, and BMI were collected as covariates.Results: Baseline characteristics (including age, gender, and BMI) showed no statistical differences between groups. No significant correlations were found between tear albumin (r=0.10, P>0.05), lactoferrin (r=0.18, P>0.05), lysozyme (r=-0.05, P>0.05) levels and OSAS.This study found no significant correlation between dry eye tear biomarkers levels and disease severity in OSAS patients. Larger-scale studies are needed to validate these findings.
Keywords: obstructive sleep apnea syndrome, dry eye, tear, Lactoferrin, lysozyme, albumin
Received: 27 Feb 2025; Accepted: 26 May 2025.
Copyright: © 2025 Wang, Hong and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wenwei Li, Department of Ophthalmology, Tongde Hospital of Zhejiang Province, Hangzhou, China
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