CASE REPORT article
Front. Med.
Sec. Nephrology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1585351
Case report and literature review: IgG4-related tubulointerstitial nephritis coexistent with systemic lupus erythematosus
Provisionally accepted
- 1Shandong Second Medical University, Weifang, China
- 2Sunshine Union Hospital, Weifang, Shandong Province, China
- 3Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
- 4AFFILIATED HOSPITAL OF SHANDONG SECOND MEDICAL UNIVERSITY, weifang, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
We present the case of a 68-year-old man with acute kidney injury that occurred following radiofrequency cardiac ablation. Laboratory tests revealed elevated serum creatinine, positivity for antinuclear and anti-double-stranded DNA antibodies, elevated IgG4 levels, and hypocomplementemia. Renal biopsy identified coexisting mesangial proliferative lupus nephritis (Class II) and IgG4-related tubulointerstitial nephritis. The patient responded well to glucocorticoid-based immunosuppressive therapy, with significant improvement in renal function. This case illustrates the rare coexistence of systemic lupus erythematosus and IgG4related kidney disease, underscoring the importance of renal biopsy in distinguishing overlapping autoimmune nephropathies.
Keywords: systemic lupus erythematosus, Lupus Nephritis, IgG-4 related diseases, IgG4-related tubulointerstitial nephritis, renal biopsy
Received: 28 Feb 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Xingfu, Guilin, Sun, Li and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ji Xingfu, Shandong Second Medical University, Weifang, China
Jing Guilin, Sunshine Union Hospital, Weifang, Shandong Province, China
Haoqi Sun, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
Xuan Li, AFFILIATED HOSPITAL OF SHANDONG SECOND MEDICAL UNIVERSITY, weifang, China
Xuexun Chen, AFFILIATED HOSPITAL OF SHANDONG SECOND MEDICAL UNIVERSITY, weifang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.