CASE REPORT article
Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1587226
This article is part of the Research TopicEosinophils in Autoimmune and Inflammatory DisordersView all articles
Diagnostic and therapeutic challenges in colonic eosinophilic abscess complicated with eosinophilic vasculitis: a case report and literature review
Provisionally accepted
- 1Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China
- 2Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China
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This case report and literature review present a 52-year-old male with a sigmoid eosinophilic abscess (EA) complicated by eosinophilic vasculitis (EoV), resulting in thrombosis and intestinal perforation. The patient presented with acute abdominal pain and melena. Laboratory tests revealed marked eosinophilia, elevated D-dimer levels, and a white blood cell count consistent with systemic inflammation. Contrast-enhanced computed tomography (CECT) identified extensive vascular thrombosis and bowel wall compromise, necessitating surgical intervention. Histopathological examination confirmed the diagnosis of EA with associated eosinophilic infiltration in the intestinal wall. This case highlights the diagnostic and therapeutic challenges of eosinophilic disorders, particularly the need for awareness of their potential complications. It also emphasizes the importance of timely intervention in managing such rare conditions. Through a review of the relevant literature, we further discuss the characteristics, differential diagnosis, and management strategies for EA and EoV.
Keywords: Colonic eosinophilic abscess, Eosinophilic vasculitis, Eosinophilia, histopathological analysis, Hypereosinophilic Syndrome
Received: 05 Mar 2025; Accepted: 24 Jun 2025.
Copyright: © 2025 Ding, Zhao, Tian and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Feng Tian, Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China
Hui Li, Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China
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